Rapid pneumococcal evolution in response to clinical interventions

Nicholas J Croucher; Simon R Harris; Christophe Fraser; Michael A Quail; John Burton; Mark van der Linden; Lesley McGee; Anne von Gottberg; Jae Hoon Song; Kwan Soo Ko; Bruno Pichon; Stephen Baker; Christopher M Parry; Lotte M Lambertsen; Dea Shahinas; Dylan R Pillai; Tim Mitchell; Gordon Dougan; Alexander Tomasz; Keith P Klugman; Julian Parkhill; William P Hanage; Stephen D Bentley

doi:10.1126/science.1198545

Rapid pneumococcal evolution in response to clinical interventions

Nicholas J Croucher, Simon R Harris, Christophe Fraser, Michael A Quail, John Burton, Mark van der Linden, Lesley McGee, Anne von Gottberg, Jae Hoon Song, Kwan Soo Ko, Bruno Pichon, Stephen Baker, Christopher M Parry, Lotte M Lambertsen, Dea Shahinas, Dylan R Pillai, Tim Mitchell, Gordon Dougan, Alexander Tomasz, Keith P KlugmanJulian Parkhill, William P Hanage, Stephen D Bentley

Immunology and Immunotherapy

Research output: Contribution to journal › Article › peer-review

618 Citations (Scopus)

Abstract

Epidemiological studies of the naturally transformable bacterial pathogen Streptococcus pneumoniae have previously been confounded by high rates of recombination. Sequencing 240 isolates of the PMEN1 (Spain(23F)-1) multidrug-resistant lineage enabled base substitutions to be distinguished from polymorphisms arising through horizontal sequence transfer. More than 700 recombinations were detected, with genes encoding major antigens frequently affected. Among these were 10 capsule-switching events, one of which accompanied a population shift as vaccine-escape serotype 19A isolates emerged in the USA after the introduction of the conjugate polysaccharide vaccine. The evolution of resistance to fluoroquinolones, rifampicin, and macrolides was observed to occur on multiple occasions. This study details how genomic plasticity within lineages of recombinogenic bacteria can permit adaptation to clinical interventions over remarkably short time scales.

Original language	English
Pages (from-to)	430-4
Number of pages	5
Journal	Science
Volume	331
Issue number	6016
DOIs	https://doi.org/10.1126/science.1198545
Publication status	Published - 2011

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Croucher, N. J., Harris, S. R., Fraser, C., Quail, M. A., Burton, J., van der Linden, M., McGee, L., von Gottberg, A., Song, J. H., Ko, K. S., Pichon, B., Baker, S., Parry, C. M., Lambertsen, L. M., Shahinas, D., Pillai, D. R., Mitchell, T., Dougan, G., Tomasz, A., ... Bentley, S. D. (2011). Rapid pneumococcal evolution in response to clinical interventions. Science, 331(6016), 430-4. https://doi.org/10.1126/science.1198545

@article{52d4e2c34557443ab9c546b7e8dc96d1,

title = "Rapid pneumococcal evolution in response to clinical interventions",

abstract = "Epidemiological studies of the naturally transformable bacterial pathogen Streptococcus pneumoniae have previously been confounded by high rates of recombination. Sequencing 240 isolates of the PMEN1 (Spain(23F)-1) multidrug-resistant lineage enabled base substitutions to be distinguished from polymorphisms arising through horizontal sequence transfer. More than 700 recombinations were detected, with genes encoding major antigens frequently affected. Among these were 10 capsule-switching events, one of which accompanied a population shift as vaccine-escape serotype 19A isolates emerged in the USA after the introduction of the conjugate polysaccharide vaccine. The evolution of resistance to fluoroquinolones, rifampicin, and macrolides was observed to occur on multiple occasions. This study details how genomic plasticity within lineages of recombinogenic bacteria can permit adaptation to clinical interventions over remarkably short time scales.",

author = "Croucher, {Nicholas J} and Harris, {Simon R} and Christophe Fraser and Quail, {Michael A} and John Burton and {van der Linden}, Mark and Lesley McGee and {von Gottberg}, Anne and Song, {Jae Hoon} and Ko, {Kwan Soo} and Bruno Pichon and Stephen Baker and Parry, {Christopher M} and Lambertsen, {Lotte M} and Dea Shahinas and Pillai, {Dylan R} and Tim Mitchell and Gordon Dougan and Alexander Tomasz and Klugman, {Keith P} and Julian Parkhill and Hanage, {William P} and Bentley, {Stephen D}",

year = "2011",

doi = "10.1126/science.1198545",

language = "English",

volume = "331",

pages = "430--4",

journal = "Science",

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Croucher, NJ, Harris, SR, Fraser, C, Quail, MA, Burton, J, van der Linden, M, McGee, L, von Gottberg, A, Song, JH, Ko, KS, Pichon, B, Baker, S, Parry, CM, Lambertsen, LM, Shahinas, D, Pillai, DR, Mitchell, T, Dougan, G, Tomasz, A, Klugman, KP, Parkhill, J, Hanage, WP & Bentley, SD 2011, 'Rapid pneumococcal evolution in response to clinical interventions', Science, vol. 331, no. 6016, pp. 430-4. https://doi.org/10.1126/science.1198545

TY - JOUR

T1 - Rapid pneumococcal evolution in response to clinical interventions

AU - Croucher, Nicholas J

AU - Harris, Simon R

AU - Fraser, Christophe

AU - Quail, Michael A

AU - Burton, John

AU - van der Linden, Mark

AU - McGee, Lesley

AU - von Gottberg, Anne

AU - Song, Jae Hoon

AU - Ko, Kwan Soo

AU - Pichon, Bruno

AU - Baker, Stephen

AU - Parry, Christopher M

AU - Lambertsen, Lotte M

AU - Shahinas, Dea

AU - Pillai, Dylan R

AU - Mitchell, Tim

AU - Dougan, Gordon

AU - Tomasz, Alexander

AU - Klugman, Keith P

AU - Parkhill, Julian

AU - Hanage, William P

AU - Bentley, Stephen D

PY - 2011

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N2 - Epidemiological studies of the naturally transformable bacterial pathogen Streptococcus pneumoniae have previously been confounded by high rates of recombination. Sequencing 240 isolates of the PMEN1 (Spain(23F)-1) multidrug-resistant lineage enabled base substitutions to be distinguished from polymorphisms arising through horizontal sequence transfer. More than 700 recombinations were detected, with genes encoding major antigens frequently affected. Among these were 10 capsule-switching events, one of which accompanied a population shift as vaccine-escape serotype 19A isolates emerged in the USA after the introduction of the conjugate polysaccharide vaccine. The evolution of resistance to fluoroquinolones, rifampicin, and macrolides was observed to occur on multiple occasions. This study details how genomic plasticity within lineages of recombinogenic bacteria can permit adaptation to clinical interventions over remarkably short time scales.

AB - Epidemiological studies of the naturally transformable bacterial pathogen Streptococcus pneumoniae have previously been confounded by high rates of recombination. Sequencing 240 isolates of the PMEN1 (Spain(23F)-1) multidrug-resistant lineage enabled base substitutions to be distinguished from polymorphisms arising through horizontal sequence transfer. More than 700 recombinations were detected, with genes encoding major antigens frequently affected. Among these were 10 capsule-switching events, one of which accompanied a population shift as vaccine-escape serotype 19A isolates emerged in the USA after the introduction of the conjugate polysaccharide vaccine. The evolution of resistance to fluoroquinolones, rifampicin, and macrolides was observed to occur on multiple occasions. This study details how genomic plasticity within lineages of recombinogenic bacteria can permit adaptation to clinical interventions over remarkably short time scales.

U2 - 10.1126/science.1198545

DO - 10.1126/science.1198545

M3 - Article

C2 - 21273480

SN - 1095-9203

VL - 331

SP - 430

EP - 434

JO - Science

JF - Science

IS - 6016

ER -

Rapid pneumococcal evolution in response to clinical interventions

Abstract

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