Randomized clinical trial to evaluate the immunogenicity of quadrivalent meningococcal conjugate and polysaccharide vaccines in adults in the United kingdom

Maheshi N Ramasamy; Elizabeth A Clutterbuck; Kathryn Haworth; Jaclyn Bowman; Omar Omar; Amber J Thompson; Geraldine Blanchard-Rohner; Ly-Mee Yu; Matthew D Snape; Andrew J Pollard

doi:10.1128/CVI.00099-14

Randomized clinical trial to evaluate the immunogenicity of quadrivalent meningococcal conjugate and polysaccharide vaccines in adults in the United kingdom

Maheshi N Ramasamy, Elizabeth A Clutterbuck, Kathryn Haworth, Jaclyn Bowman, Omar Omar, Amber J Thompson, Geraldine Blanchard-Rohner, Ly-Mee Yu, Matthew D Snape, Andrew J Pollard

Birmingham Clinical Trials Unit

Research output: Contribution to journal › Article › peer-review

8 Citations (Scopus)

Abstract

Meningococcal conjugate vaccines are today successfully deployed in universal programs for children and adolescents in different geographic regions to control meningitis and septicemia. However, in adults, the advantages of these conjugates over the older polysaccharide vaccines are less clear. In this randomized clinical trial, we demonstrated that both conjugate and polysaccharide quadrivalent meningococcal vaccines elicit protective antibody responses in adults aged 18 to 70. (This study has been registered at www.clinicaltrials.gov under registration no. NCT00901940.).

Original language	English
Pages (from-to)	1164-8
Number of pages	5
Journal	Clinical and Vaccine Immunology
Volume	21
Issue number	8
DOIs	https://doi.org/10.1128/CVI.00099-14
Publication status	Published - Aug 2014

Bibliographical note

Keywords

Adult
Aged
Antibodies, Bacterial/immunology
Antigens, Bacterial/immunology
Female
Humans
Male
Meningitis, Meningococcal/immunology
Meningococcal Vaccines/immunology
Middle Aged
Neisseria meningitidis/immunology
Polysaccharides, Bacterial/immunology
United Kingdom
Vaccination
Vaccines, Conjugate/immunology
Young Adult

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1128/CVI.00099-14

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Ramasamy, M. N., Clutterbuck, E. A., Haworth, K., Bowman, J., Omar, O., Thompson, A. J., Blanchard-Rohner, G., Yu, L.-M., Snape, M. D., & Pollard, A. J. (2014). Randomized clinical trial to evaluate the immunogenicity of quadrivalent meningococcal conjugate and polysaccharide vaccines in adults in the United kingdom. Clinical and Vaccine Immunology, 21(8), 1164-8. https://doi.org/10.1128/CVI.00099-14

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title = "Randomized clinical trial to evaluate the immunogenicity of quadrivalent meningococcal conjugate and polysaccharide vaccines in adults in the United kingdom",

abstract = "Meningococcal conjugate vaccines are today successfully deployed in universal programs for children and adolescents in different geographic regions to control meningitis and septicemia. However, in adults, the advantages of these conjugates over the older polysaccharide vaccines are less clear. In this randomized clinical trial, we demonstrated that both conjugate and polysaccharide quadrivalent meningococcal vaccines elicit protective antibody responses in adults aged 18 to 70. (This study has been registered at www.clinicaltrials.gov under registration no. NCT00901940.). ",

keywords = "Adult, Aged, Antibodies, Bacterial/immunology, Antigens, Bacterial/immunology, Female, Humans, Male, Meningitis, Meningococcal/immunology, Meningococcal Vaccines/immunology, Middle Aged, Neisseria meningitidis/immunology, Polysaccharides, Bacterial/immunology, United Kingdom, Vaccination, Vaccines, Conjugate/immunology, Young Adult",

author = "Ramasamy, {Maheshi N} and Clutterbuck, {Elizabeth A} and Kathryn Haworth and Jaclyn Bowman and Omar Omar and Thompson, {Amber J} and Geraldine Blanchard-Rohner and Ly-Mee Yu and Snape, {Matthew D} and Pollard, {Andrew J}",

year = "2014",

month = aug,

doi = "10.1128/CVI.00099-14",

language = "English",

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pages = "1164--8",

journal = "Clinical and Vaccine Immunology",

issn = "1556-6811",

publisher = "American Society for Microbiology",

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Ramasamy, MN, Clutterbuck, EA, Haworth, K, Bowman, J, Omar, O, Thompson, AJ, Blanchard-Rohner, G, Yu, L-M, Snape, MD & Pollard, AJ 2014, 'Randomized clinical trial to evaluate the immunogenicity of quadrivalent meningococcal conjugate and polysaccharide vaccines in adults in the United kingdom', Clinical and Vaccine Immunology, vol. 21, no. 8, pp. 1164-8. https://doi.org/10.1128/CVI.00099-14

Randomized clinical trial to evaluate the immunogenicity of quadrivalent meningococcal conjugate and polysaccharide vaccines in adults in the United kingdom. / Ramasamy, Maheshi N; Clutterbuck, Elizabeth A; Haworth, Kathryn et al.
In: Clinical and Vaccine Immunology, Vol. 21, No. 8, 08.2014, p. 1164-8.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Randomized clinical trial to evaluate the immunogenicity of quadrivalent meningococcal conjugate and polysaccharide vaccines in adults in the United kingdom

AU - Ramasamy, Maheshi N

AU - Clutterbuck, Elizabeth A

AU - Haworth, Kathryn

AU - Bowman, Jaclyn

AU - Omar, Omar

AU - Thompson, Amber J

AU - Blanchard-Rohner, Geraldine

AU - Yu, Ly-Mee

AU - Snape, Matthew D

AU - Pollard, Andrew J

PY - 2014/8

Y1 - 2014/8

N2 - Meningococcal conjugate vaccines are today successfully deployed in universal programs for children and adolescents in different geographic regions to control meningitis and septicemia. However, in adults, the advantages of these conjugates over the older polysaccharide vaccines are less clear. In this randomized clinical trial, we demonstrated that both conjugate and polysaccharide quadrivalent meningococcal vaccines elicit protective antibody responses in adults aged 18 to 70. (This study has been registered at www.clinicaltrials.gov under registration no. NCT00901940.).

AB - Meningococcal conjugate vaccines are today successfully deployed in universal programs for children and adolescents in different geographic regions to control meningitis and septicemia. However, in adults, the advantages of these conjugates over the older polysaccharide vaccines are less clear. In this randomized clinical trial, we demonstrated that both conjugate and polysaccharide quadrivalent meningococcal vaccines elicit protective antibody responses in adults aged 18 to 70. (This study has been registered at www.clinicaltrials.gov under registration no. NCT00901940.).

KW - Adult

KW - Aged

KW - Antibodies, Bacterial/immunology

KW - Antigens, Bacterial/immunology

KW - Female

KW - Humans

KW - Male

KW - Meningitis, Meningococcal/immunology

KW - Meningococcal Vaccines/immunology

KW - Middle Aged

KW - Neisseria meningitidis/immunology

KW - Polysaccharides, Bacterial/immunology

KW - United Kingdom

KW - Vaccination

KW - Vaccines, Conjugate/immunology

KW - Young Adult

U2 - 10.1128/CVI.00099-14

DO - 10.1128/CVI.00099-14

M3 - Article

C2 - 24964805

SN - 1556-6811

VL - 21

SP - 1164

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JO - Clinical and Vaccine Immunology

JF - Clinical and Vaccine Immunology

IS - 8

ER -

Randomized clinical trial to evaluate the immunogenicity of quadrivalent meningococcal conjugate and polysaccharide vaccines in adults in the United kingdom

Abstract

Bibliographical note

Keywords

UN SDGs

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