Randomized clinical trial of long-acting oxytetracycline, foot trimming, and flunixine meglumine on time to recovery in sheep with footrot

J. Kaler, S. L.S. Daniels, J. L. Wright, L. E. Green

Research output: Contribution to journalArticlepeer-review

68 Citations (Scopus)

Abstract

Background: Internationally, foot trimming is used by most farmers, and parenteral antibacterials by some, to treat sheep with footrot. Nonsteroidal anti-inflammatory drugs (NSAID) are sometimes used. No clinical trials have compared these treatments. Objectives: To investigate the above treatments on time to recovery from lameness and foot lesions in sheep with footrot. Animals: Fifty-three sheep with footrot on a commercial farm in England. Methods: In a randomized factorial design, the sheep were allocated to 6 treatment groups. The treatments were oxytetracycline spray to all sheep (positive control) and one or more of parenteral administration of long-acting oxytetracycline, flunixine meglumine, and foot trimming on day 1 or 6 of diagnosis. Follow-up was for 15 days. Time to recovery from lameness and lesions was investigated with discrete-time survival models. Results: There was significant association (P <.05) between recovery from lameness and lesions. Sheep receiving antibacterials parenterally recovered faster from lameness (odds ratio [OR]: 4.92 [1.20-20.10]) and lesions (OR: 5.11 [1.16-22.4]) than positive controls, whereas sheep foot trimmed on day 1 (lameness-OR: 0.05 [0.005-0.51]; lesions-OR: 0.06 [0.008-0.45]) or day 6 of diagnosis (lameness-OR: 0.07 [0.01-0.72]; lesions-OR: 0.07 [0.01-0.56]) recovered more slowly than positive controls. NSAID had no significant effect on recovery. Conclusions and Clinical Importance: If foot trimming on day 1 or 6 of diagnosis was stopped and parenteral antibacterials were used, then over 1 million sheep/annum lame with footrot in the United Kingdom would recover more rapidly with benefits to productivity. Globally, this figure would be much higher.

Original languageEnglish
Pages (from-to)420-425
Number of pages6
JournalJournal of Veterinary Internal Medicine
Volume24
Issue number2
DOIs
Publication statusPublished - Mar 2010

Keywords

  • Antibacterials
  • Dichelobacter nodosus
  • Infectious disease
  • Ovine

ASJC Scopus subject areas

  • veterinary(all)

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