Raman spectroscopic molecular fingerprinting of biomarkers for inflammatory bowel disease

Emma Buchan; Jonathan James Stanley Rickard; Pola Goldberg Oppenheimer

doi:10.1002/ctm2.1345

Raman spectroscopic molecular fingerprinting of biomarkers for inflammatory bowel disease

Emma Buchan, Jonathan James Stanley Rickard, Pola Goldberg Oppenheimer^*

^*Corresponding author for this work

Research output: Contribution to journal › Letter › peer-review

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Abstract

Inflammatory bowel diseases (IBDs) are increasingly dif-ficult to diagnose and differentiate despite serologicaltesting, endoscopic and histopathological assessments. Nosingle biomarker exists to predict IBD in a timely man-ner. We have developed a spectral library of candidateIBD-biomarkers,establishingcharacteristicmolecularbar-codes, through a combination of multiplex spectroscopicprofiling simultaneously detecting a panel of identifiedbiomarkers with an advanced artificial intelligence (AI)networkandclassifyingpatientsaccordingtodiseasestate.This lays the platform for rapidly and non-invasivelydetecting IBD and discriminating between the subtypesfor timely diagnoses, biomarker discovery, patient strati-fication and further potential significant developments ofdiagnostic methodologies and therapeutic monitoring

Original language	English
Article number	e1345
Number of pages	6
Journal	Clinical and Translational Medicine
Volume	13
Issue number	11
DOIs	https://doi.org/10.1002/ctm2.1345
Publication status	Published - 3 Nov 2023

Bibliographical note

Acknowledgments:
We acknowledge funding from the Wellcome Trust (174ISSFPP) and the EPSRC (EP/W004593/1, EP/V029983/1). We would like to thank Dr Jinglei Yu for assisting with the mass spectrometry data analysis.

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BuchanE2023RamanFinal published version, 1.62 MBLicence: Creative Commons: Attribution (CC BY)

1 Active
2 Finished

Window into the Mind: Handheld Spectroscopic Eye-safe Device (EyeD) for Neurodiagnostics
Goldberg Oppenheimer, P. (Principal Investigator)
Engineering & Physical Science Research Council
1/05/21 → 30/04/25
Project: Research
A smart, multi-purpose technology for diagnostics, analytics and drug delivery
Goldberg Oppenheimer, P. (Principal Investigator) & Mendes, P. (Co-Investigator)
Engineering & Physical Science Research Council
1/10/21 → 30/06/23
Project: Research Councils
WT ISSF14/15 A new frontier in a development of nanoplasmonic-metamaterial detectors from DNA building blocks
Goldberg Oppenheimer, P. (Principal Investigator)
Wellcome Trust
15/04/15 → 30/09/17
Project: Research

Cite this

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title = "Raman spectroscopic molecular fingerprinting of biomarkers for inflammatory bowel disease",

abstract = "Inflammatory bowel diseases (IBDs) are increasingly dif-ficult to diagnose and differentiate despite serologicaltesting, endoscopic and histopathological assessments. Nosingle biomarker exists to predict IBD in a timely man-ner. We have developed a spectral library of candidateIBD-biomarkers,establishingcharacteristicmolecularbar-codes, through a combination of multiplex spectroscopicprofiling simultaneously detecting a panel of identifiedbiomarkers with an advanced artificial intelligence (AI)networkandclassifyingpatientsaccordingtodiseasestate.This lays the platform for rapidly and non-invasivelydetecting IBD and discriminating between the subtypesfor timely diagnoses, biomarker discovery, patient strati-fication and further potential significant developments ofdiagnostic methodologies and therapeutic monitoring",

author = "Emma Buchan and Rickard, {Jonathan James Stanley} and Oppenheimer, {Pola Goldberg}",

note = "Acknowledgments: We acknowledge funding from the Wellcome Trust (174ISSFPP) and the EPSRC (EP/W004593/1, EP/V029983/1). We would like to thank Dr Jinglei Yu for assisting with the mass spectrometry data analysis.",

year = "2023",

month = nov,

day = "3",

doi = "10.1002/ctm2.1345",

language = "English",

volume = "13",

journal = "Clinical and Translational Medicine",

issn = "2001-1326",

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T1 - Raman spectroscopic molecular fingerprinting of biomarkers for inflammatory bowel disease

AU - Buchan, Emma

AU - Rickard, Jonathan James Stanley

AU - Oppenheimer, Pola Goldberg

N1 - Acknowledgments: We acknowledge funding from the Wellcome Trust (174ISSFPP) and the EPSRC (EP/W004593/1, EP/V029983/1). We would like to thank Dr Jinglei Yu for assisting with the mass spectrometry data analysis.

PY - 2023/11/3

Y1 - 2023/11/3

N2 - Inflammatory bowel diseases (IBDs) are increasingly dif-ficult to diagnose and differentiate despite serologicaltesting, endoscopic and histopathological assessments. Nosingle biomarker exists to predict IBD in a timely man-ner. We have developed a spectral library of candidateIBD-biomarkers,establishingcharacteristicmolecularbar-codes, through a combination of multiplex spectroscopicprofiling simultaneously detecting a panel of identifiedbiomarkers with an advanced artificial intelligence (AI)networkandclassifyingpatientsaccordingtodiseasestate.This lays the platform for rapidly and non-invasivelydetecting IBD and discriminating between the subtypesfor timely diagnoses, biomarker discovery, patient strati-fication and further potential significant developments ofdiagnostic methodologies and therapeutic monitoring

AB - Inflammatory bowel diseases (IBDs) are increasingly dif-ficult to diagnose and differentiate despite serologicaltesting, endoscopic and histopathological assessments. Nosingle biomarker exists to predict IBD in a timely man-ner. We have developed a spectral library of candidateIBD-biomarkers,establishingcharacteristicmolecularbar-codes, through a combination of multiplex spectroscopicprofiling simultaneously detecting a panel of identifiedbiomarkers with an advanced artificial intelligence (AI)networkandclassifyingpatientsaccordingtodiseasestate.This lays the platform for rapidly and non-invasivelydetecting IBD and discriminating between the subtypesfor timely diagnoses, biomarker discovery, patient strati-fication and further potential significant developments ofdiagnostic methodologies and therapeutic monitoring

U2 - 10.1002/ctm2.1345

DO - 10.1002/ctm2.1345

M3 - Letter

C2 - 37921275

SN - 2001-1326

VL - 13

JO - Clinical and Translational Medicine

JF - Clinical and Translational Medicine

IS - 11

M1 - e1345

ER -

Raman spectroscopic molecular fingerprinting of biomarkers for inflammatory bowel disease

Abstract

Bibliographical note

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Projects

Window into the Mind: Handheld Spectroscopic Eye-safe Device (EyeD) for Neurodiagnostics

A smart, multi-purpose technology for diagnostics, analytics and drug delivery

WT ISSF14/15 A new frontier in a development of nanoplasmonic-metamaterial detectors from DNA building blocks

Cite this