Radiosynthesis and reactivity of N-[11C]methyl carbamoylimidazole

Manikandan Kadirvel, Déborah Cardoso, Sally Freeman, Gavin Brown

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)

Abstract

N-Methyl carbamoylimidazole is a safe and practical alternative to methyl isocyanate for carbamoylation reactions. We have developed a new chemical route for its synthesis from methyl iodide and applied this to the synthesis of N-[11C]methyl carbamoylimidazole as a new [11C]synthon to radiolabel biomolecules for PET imaging research. N-[11C]methyl carbamoylimidazole was prepared from [11C]methyl iodide in 70–74% radiochemical yield (decay corrected) and can be used in situ for further reaction without purification. The reactivity of N-[11C]methyl carbamoylimidazole was demonstrated in a series of [11C]carbamoylation reactions.

Original languageEnglish
Pages (from-to)977-984
Number of pages8
JournalJournal of Radioanalytical and Nuclear Chemistry
Volume317
Issue number2
Early online date19 Jun 2018
DOIs
Publication statusPublished - Aug 2018

Bibliographical note

Publisher Copyright:
© 2018, The Author(s).

Keywords

  • C
  • Carbamoylation
  • Methyl isocyanate
  • PET
  • Radiochemistry

ASJC Scopus subject areas

  • Analytical Chemistry
  • Nuclear Energy and Engineering
  • Radiology Nuclear Medicine and imaging
  • Pollution
  • Spectroscopy
  • Public Health, Environmental and Occupational Health
  • Health, Toxicology and Mutagenesis

Fingerprint

Dive into the research topics of 'Radiosynthesis and reactivity of N-[11C]methyl carbamoylimidazole'. Together they form a unique fingerprint.

Cite this