Abstract
Objective
Relative to SLE, epidemiologic studies on chronic cutaneous lupus
erythematosus (CCLE) are rare and limited to populations without racial diversity. We sought to provide minimum estimates of the incidence of primary CCLE (CCLE in absence of SLE) in a predominantly white and black population in the Southestern United States.
Methods
The Georgia Lupus Registry used multiple sources for case finding, including
dermatology and rheumatology practices, multispecialty healthcare facilities, and
dermatopathology reports. Cases with a clinical or clinical-histological diagnosis of CCLE were classified as definite. Cases ascertained exclusively from dermatopathology reports were categorized as probable. Age-standardized incidence rates stratified by sex and race were calculated for discoid lupus erythematosus (DLE) in particular and for CCLE in general.
Results
The overall age-adjusted estimates for combined (definite and probable) CCLE were 3.9/100,000 person-years (95% CI: 3.4,4.5). The overall age-adjusted incidence of definite and combined DLE were 2.9 (95% CI: 2.4,3.4) and 3.7 (95% CI: 3.2,4.3) per 100,000 personyears, respectively. With capture-recapture methods, the age-adjusted incidence of definite DLE increased to 4.0 (95% CI: 3.2,4.3). Black-to-white and female-to-male incidence ratios were 5.4 and 3.1 for definite DLE.
Conclusion
Our findings underscore striking racial disparities in the susceptibility for
primary CCLE, with black people experiencing between three and five-fold increased incidence of CCLE in general and DLE in particular, compared to white people. Gender differences were consistent with those reported previously, with a three times higher risk of DLE in females compared to males.
Relative to SLE, epidemiologic studies on chronic cutaneous lupus
erythematosus (CCLE) are rare and limited to populations without racial diversity. We sought to provide minimum estimates of the incidence of primary CCLE (CCLE in absence of SLE) in a predominantly white and black population in the Southestern United States.
Methods
The Georgia Lupus Registry used multiple sources for case finding, including
dermatology and rheumatology practices, multispecialty healthcare facilities, and
dermatopathology reports. Cases with a clinical or clinical-histological diagnosis of CCLE were classified as definite. Cases ascertained exclusively from dermatopathology reports were categorized as probable. Age-standardized incidence rates stratified by sex and race were calculated for discoid lupus erythematosus (DLE) in particular and for CCLE in general.
Results
The overall age-adjusted estimates for combined (definite and probable) CCLE were 3.9/100,000 person-years (95% CI: 3.4,4.5). The overall age-adjusted incidence of definite and combined DLE were 2.9 (95% CI: 2.4,3.4) and 3.7 (95% CI: 3.2,4.3) per 100,000 personyears, respectively. With capture-recapture methods, the age-adjusted incidence of definite DLE increased to 4.0 (95% CI: 3.2,4.3). Black-to-white and female-to-male incidence ratios were 5.4 and 3.1 for definite DLE.
Conclusion
Our findings underscore striking racial disparities in the susceptibility for
primary CCLE, with black people experiencing between three and five-fold increased incidence of CCLE in general and DLE in particular, compared to white people. Gender differences were consistent with those reported previously, with a three times higher risk of DLE in females compared to males.
| Original language | English |
|---|---|
| Journal | Arthritis Care & Research |
| Early online date | 18 Apr 2018 |
| DOIs | |
| Publication status | E-pub ahead of print - 18 Apr 2018 |