Quantitative Bioluminescence Tomography-guided System for Conformal Irradiation In Vivo

Xiangkun Xu; Zijian Deng; Hamid Dehghani; Iulian Iordachita; Michael Lim; John W. Wong; Ken Kang-Hsin Wang

Quantitative Bioluminescence Tomography-guided System for Conformal Irradiation In Vivo

Xiangkun Xu, Zijian Deng, Hamid Dehghani, Iulian Iordachita, Michael Lim, John W. Wong, Ken Kang-Hsin Wang

Computer Science

Research output: Working paper/Preprint › Preprint

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Abstract

Although cone-beam CT (CBCT) has been used to guide irradiation for pre-clinical radiotherapy(RT) research, it is limited to localize soft tissue target especially in a low imaging contrast environment. Knowledge of target shape is a fundamental need for RT. Without such information to guide radiation, normal tissue can be irradiated unnecessarily, leading to experimental uncertainties. Recognition of this need led us to develop quantitative bioluminescence tomography (QBLT), which provides strong imaging contrast to localize optical targets. We demonstrated its capability of guiding conformal RT using an orthotopic bioluminescent glioblastoma (GBM) model. With multi-projection and multi-spectral bioluminescence imaging and a novel spectral derivative method, our QBLT system is able to reconstruct GBM with localization accuracy

Original language	English
Publication status	Published - 6 Oct 2020

Keywords

physics.med-ph

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2010.02492v1

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title = "Quantitative Bioluminescence Tomography-guided System for Conformal Irradiation In Vivo",

abstract = "Although cone-beam CT (CBCT) has been used to guide irradiation for pre-clinical radiotherapy(RT) research, it is limited to localize soft tissue target especially in a low imaging contrast environment. Knowledge of target shape is a fundamental need for RT. Without such information to guide radiation, normal tissue can be irradiated unnecessarily, leading to experimental uncertainties. Recognition of this need led us to develop quantitative bioluminescence tomography (QBLT), which provides strong imaging contrast to localize optical targets. We demonstrated its capability of guiding conformal RT using an orthotopic bioluminescent glioblastoma (GBM) model. With multi-projection and multi-spectral bioluminescence imaging and a novel spectral derivative method, our QBLT system is able to reconstruct GBM with localization accuracy ",

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author = "Xiangkun Xu and Zijian Deng and Hamid Dehghani and Iulian Iordachita and Michael Lim and Wong, {John W.} and Wang, {Ken Kang-Hsin}",

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T1 - Quantitative Bioluminescence Tomography-guided System for Conformal Irradiation In Vivo

AU - Xu, Xiangkun

AU - Deng, Zijian

AU - Dehghani, Hamid

AU - Iordachita, Iulian

AU - Lim, Michael

AU - Wong, John W.

AU - Wang, Ken Kang-Hsin

PY - 2020/10/6

Y1 - 2020/10/6

N2 - Although cone-beam CT (CBCT) has been used to guide irradiation for pre-clinical radiotherapy(RT) research, it is limited to localize soft tissue target especially in a low imaging contrast environment. Knowledge of target shape is a fundamental need for RT. Without such information to guide radiation, normal tissue can be irradiated unnecessarily, leading to experimental uncertainties. Recognition of this need led us to develop quantitative bioluminescence tomography (QBLT), which provides strong imaging contrast to localize optical targets. We demonstrated its capability of guiding conformal RT using an orthotopic bioluminescent glioblastoma (GBM) model. With multi-projection and multi-spectral bioluminescence imaging and a novel spectral derivative method, our QBLT system is able to reconstruct GBM with localization accuracy

AB - Although cone-beam CT (CBCT) has been used to guide irradiation for pre-clinical radiotherapy(RT) research, it is limited to localize soft tissue target especially in a low imaging contrast environment. Knowledge of target shape is a fundamental need for RT. Without such information to guide radiation, normal tissue can be irradiated unnecessarily, leading to experimental uncertainties. Recognition of this need led us to develop quantitative bioluminescence tomography (QBLT), which provides strong imaging contrast to localize optical targets. We demonstrated its capability of guiding conformal RT using an orthotopic bioluminescent glioblastoma (GBM) model. With multi-projection and multi-spectral bioluminescence imaging and a novel spectral derivative method, our QBLT system is able to reconstruct GBM with localization accuracy

KW - physics.med-ph

M3 - Preprint

BT - Quantitative Bioluminescence Tomography-guided System for Conformal Irradiation In Vivo

ER -

Quantitative Bioluminescence Tomography-guided System for Conformal Irradiation In Vivo

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