Quantification of volume and size distribution of internalised calcium phosphate particles and their influence on cell fate

Richard L. Williams; Isaac Vizcaíno-Castón; Liam M. Grover

doi:10.1039/c4bm00238e

Quantification of volume and size distribution of internalised calcium phosphate particles and their influence on cell fate

Richard L. Williams
, Isaac Vizcaíno-Castón
, Liam M. Grover^*

^*Corresponding author for this work

Chemical Engineering

Research output: Contribution to journal › Article › peer-review

1 Citation (Scopus)

Abstract

We report preliminary findings suggesting that the diameter of the internalised calcium phosphate particles is critical to cell fate with particles/aggregates of particles of larger than 1.5 μm not processed by lysosomes leading to cell death. This has significant implications for the design of medical materials even from those consisting of non-toxic calcium phosphate salts.

Original language	English
Pages (from-to)	1723-1726
Number of pages	4
Journal	Biomaterials Science
Volume	2
Issue number	12
Early online date	5 Aug 2014
DOIs	https://doi.org/10.1039/c4bm00238e
Publication status	Published - 12 Dec 2014

ASJC Scopus subject areas

General Materials Science
Biomedical Engineering

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title = "Quantification of volume and size distribution of internalised calcium phosphate particles and their influence on cell fate",

abstract = "We report preliminary findings suggesting that the diameter of the internalised calcium phosphate particles is critical to cell fate with particles/aggregates of particles of larger than 1.5 μm not processed by lysosomes leading to cell death. This has significant implications for the design of medical materials even from those consisting of non-toxic calcium phosphate salts.",

author = "Williams, \{Richard L.\} and Isaac Vizca{\'i}no-Cast{\'o}n and Grover, \{Liam M.\}",

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AU - Williams, Richard L.

AU - Vizcaíno-Castón, Isaac

AU - Grover, Liam M.

PY - 2014/12/12

Y1 - 2014/12/12

N2 - We report preliminary findings suggesting that the diameter of the internalised calcium phosphate particles is critical to cell fate with particles/aggregates of particles of larger than 1.5 μm not processed by lysosomes leading to cell death. This has significant implications for the design of medical materials even from those consisting of non-toxic calcium phosphate salts.

AB - We report preliminary findings suggesting that the diameter of the internalised calcium phosphate particles is critical to cell fate with particles/aggregates of particles of larger than 1.5 μm not processed by lysosomes leading to cell death. This has significant implications for the design of medical materials even from those consisting of non-toxic calcium phosphate salts.

UR - https://www.scopus.com/pages/publications/84908504855

U2 - 10.1039/c4bm00238e

DO - 10.1039/c4bm00238e

M3 - Article

AN - SCOPUS:84908504855

SN - 2047-4830

VL - 2

SP - 1723

EP - 1726

JO - Biomaterials Science

JF - Biomaterials Science

IS - 12

ER -

Quantification of volume and size distribution of internalised calcium phosphate particles and their influence on cell fate

Abstract

ASJC Scopus subject areas

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