Quality and Completeness of Myocardial Infarction Recording in Clinical Practice Research Datalink Aurum

Rebecca Persson; Todd Sponholtz; Catherine Vasilakis-Scaramozza; Katrina Wilcox Hagberg; Tim Williams; Dipak Kotecha; Puja Myles; Susan S Jick

doi:10.2147/CLEP.S319245

Quality and Completeness of Myocardial Infarction Recording in Clinical Practice Research Datalink Aurum

Rebecca Persson, Todd Sponholtz, Catherine Vasilakis-Scaramozza, Katrina Wilcox Hagberg, Tim Williams, Dipak Kotecha, Puja Myles, Susan S Jick^*

^*Corresponding author for this work

Cardiovascular Sciences

Research output: Contribution to journal › Article › peer-review

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Abstract

BACKGROUND: Validation studies of the Clinical Practice Research Datalink (CPRD) Aurum database in the UK are critical for making decisions about its suitability and validity for research purposes.

OBJECTIVE: To examine data source agreement of myocardial infarction (MI) diagnoses recorded in CPRD Aurum compared with linked Hospital Episode Statistics (HES) data. This comparison provides information on CPRD Aurum data correctness (accuracy, validity) and completeness (presence, missingness).

METHODS: Patients with MI diagnoses recorded in either data source were selected from a random sample of 50,000 patients in CPRD Aurum with HES linkage (1997-2017). Correctness was defined as the proportion of MI cases in CPRD Aurum with a concordant MI diagnosis recorded in HES or with strong supporting evidence in either data source. Completeness was defined as the proportion of patients with primary HES-coded MIs with strong supporting evidence that were also present in CPRD Aurum.

RESULTS: There were 1260 patients with MI recorded in the CPRD Aurum sample. The overall correctness of the recorded MI diagnoses was 94%: 986 patients (78%) had concordant diagnoses in HES within 90 days; 123 (10%) were concordant with HES, but with an inconclusive date and another 71 (6%) had strong supporting evidence for being a true MI case. There were 1125 patients with MI recorded in HES primary diagnosis fields with strong supporting evidence in either data source. Of these, 880 (78%) were present in CPRD Aurum, with completeness somewhat higher in more recent years.

CONCLUSION: MI diagnoses recorded in CPRD Aurum were highly likely to be correct, supporting its use in clinical research studies. Completeness was lower, indicating the need for data linkage for some studies.

Original language	English
Pages (from-to)	745-753
Number of pages	9
Journal	Clinical epidemiology
Volume	2021
Issue number	13
DOIs	https://doi.org/10.2147/CLEP.S319245
Publication status	Published - 24 Aug 2021

Bibliographical note

Keywords

clinical practice research datalink
CPRD Aurum
data validation
data completeness
data quality

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10.2147/CLEP.S319245Licence: Creative Commons: Attribution (CC BY)

PerssonR2021QualityFinal published version, 4.7 MBLicence: Creative Commons: Attribution (CC BY)

Cardiotonic steroids in patients with atrial fibrillation and heart failure: Quantification, functional effects and personalisation of digoxin therapy
Arlt, W., Pavlovic, D., Taylor, A., Kotecha, D. & Kirchhof, P.
British Heart Foundation
1/06/18 → 30/05/21
Project: Research
H2020_COLLAB(IMI-JU)_BIGDATA@HEART
Kotecha, D. & Kirchhof, P.
European Commission
1/03/17 → 28/02/23
Project: Research
Optimising rate-control therapy in older patients with AF - a training fellowship and pilot study focused on improving quality of life (RATE-AF)
Mathers, J., Calvert, M., Kotecha, D., Deeks, J., Kirchhof, P., Jowett, S. & Windridge, D.
NIHR TRAINEES COORDINATING CENTRE
1/01/16 → 31/12/19
Project: Other Government Departments

Cite this

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title = "Quality and Completeness of Myocardial Infarction Recording in Clinical Practice Research Datalink Aurum",

abstract = "BACKGROUND: Validation studies of the Clinical Practice Research Datalink (CPRD) Aurum database in the UK are critical for making decisions about its suitability and validity for research purposes.OBJECTIVE: To examine data source agreement of myocardial infarction (MI) diagnoses recorded in CPRD Aurum compared with linked Hospital Episode Statistics (HES) data. This comparison provides information on CPRD Aurum data correctness (accuracy, validity) and completeness (presence, missingness).METHODS: Patients with MI diagnoses recorded in either data source were selected from a random sample of 50,000 patients in CPRD Aurum with HES linkage (1997-2017). Correctness was defined as the proportion of MI cases in CPRD Aurum with a concordant MI diagnosis recorded in HES or with strong supporting evidence in either data source. Completeness was defined as the proportion of patients with primary HES-coded MIs with strong supporting evidence that were also present in CPRD Aurum.RESULTS: There were 1260 patients with MI recorded in the CPRD Aurum sample. The overall correctness of the recorded MI diagnoses was 94%: 986 patients (78%) had concordant diagnoses in HES within 90 days; 123 (10%) were concordant with HES, but with an inconclusive date and another 71 (6%) had strong supporting evidence for being a true MI case. There were 1125 patients with MI recorded in HES primary diagnosis fields with strong supporting evidence in either data source. Of these, 880 (78%) were present in CPRD Aurum, with completeness somewhat higher in more recent years.CONCLUSION: MI diagnoses recorded in CPRD Aurum were highly likely to be correct, supporting its use in clinical research studies. Completeness was lower, indicating the need for data linkage for some studies.",

keywords = "clinical practice research datalink, CPRD Aurum, data validation, data completeness, data quality",

author = "Rebecca Persson and Todd Sponholtz and Catherine Vasilakis-Scaramozza and Hagberg, {Katrina Wilcox} and Tim Williams and Dipak Kotecha and Puja Myles and Jick, {Susan S}",

note = "{\textcopyright} 2021 Persson et al.",

year = "2021",

month = aug,

day = "24",

doi = "10.2147/CLEP.S319245",

language = "English",

volume = "2021",

pages = "745--753",

journal = "Clinical epidemiology",

issn = "1179-1349",

publisher = "Dove Medical Press",

number = "13",

}

TY - JOUR

T1 - Quality and Completeness of Myocardial Infarction Recording in Clinical Practice Research Datalink Aurum

AU - Persson, Rebecca

AU - Sponholtz, Todd

AU - Vasilakis-Scaramozza, Catherine

AU - Hagberg, Katrina Wilcox

AU - Williams, Tim

AU - Kotecha, Dipak

AU - Myles, Puja

AU - Jick, Susan S

PY - 2021/8/24

Y1 - 2021/8/24

N2 - BACKGROUND: Validation studies of the Clinical Practice Research Datalink (CPRD) Aurum database in the UK are critical for making decisions about its suitability and validity for research purposes.OBJECTIVE: To examine data source agreement of myocardial infarction (MI) diagnoses recorded in CPRD Aurum compared with linked Hospital Episode Statistics (HES) data. This comparison provides information on CPRD Aurum data correctness (accuracy, validity) and completeness (presence, missingness).METHODS: Patients with MI diagnoses recorded in either data source were selected from a random sample of 50,000 patients in CPRD Aurum with HES linkage (1997-2017). Correctness was defined as the proportion of MI cases in CPRD Aurum with a concordant MI diagnosis recorded in HES or with strong supporting evidence in either data source. Completeness was defined as the proportion of patients with primary HES-coded MIs with strong supporting evidence that were also present in CPRD Aurum.RESULTS: There were 1260 patients with MI recorded in the CPRD Aurum sample. The overall correctness of the recorded MI diagnoses was 94%: 986 patients (78%) had concordant diagnoses in HES within 90 days; 123 (10%) were concordant with HES, but with an inconclusive date and another 71 (6%) had strong supporting evidence for being a true MI case. There were 1125 patients with MI recorded in HES primary diagnosis fields with strong supporting evidence in either data source. Of these, 880 (78%) were present in CPRD Aurum, with completeness somewhat higher in more recent years.CONCLUSION: MI diagnoses recorded in CPRD Aurum were highly likely to be correct, supporting its use in clinical research studies. Completeness was lower, indicating the need for data linkage for some studies.

AB - BACKGROUND: Validation studies of the Clinical Practice Research Datalink (CPRD) Aurum database in the UK are critical for making decisions about its suitability and validity for research purposes.OBJECTIVE: To examine data source agreement of myocardial infarction (MI) diagnoses recorded in CPRD Aurum compared with linked Hospital Episode Statistics (HES) data. This comparison provides information on CPRD Aurum data correctness (accuracy, validity) and completeness (presence, missingness).METHODS: Patients with MI diagnoses recorded in either data source were selected from a random sample of 50,000 patients in CPRD Aurum with HES linkage (1997-2017). Correctness was defined as the proportion of MI cases in CPRD Aurum with a concordant MI diagnosis recorded in HES or with strong supporting evidence in either data source. Completeness was defined as the proportion of patients with primary HES-coded MIs with strong supporting evidence that were also present in CPRD Aurum.RESULTS: There were 1260 patients with MI recorded in the CPRD Aurum sample. The overall correctness of the recorded MI diagnoses was 94%: 986 patients (78%) had concordant diagnoses in HES within 90 days; 123 (10%) were concordant with HES, but with an inconclusive date and another 71 (6%) had strong supporting evidence for being a true MI case. There were 1125 patients with MI recorded in HES primary diagnosis fields with strong supporting evidence in either data source. Of these, 880 (78%) were present in CPRD Aurum, with completeness somewhat higher in more recent years.CONCLUSION: MI diagnoses recorded in CPRD Aurum were highly likely to be correct, supporting its use in clinical research studies. Completeness was lower, indicating the need for data linkage for some studies.

KW - clinical practice research datalink

KW - CPRD Aurum

KW - data validation

KW - data completeness

KW - data quality

U2 - 10.2147/CLEP.S319245

DO - 10.2147/CLEP.S319245

M3 - Article

C2 - 34471387

SN - 1179-1349

VL - 2021

SP - 745

EP - 753

JO - Clinical epidemiology

JF - Clinical epidemiology

IS - 13

ER -

Quality and Completeness of Myocardial Infarction Recording in Clinical Practice Research Datalink Aurum

Abstract

Bibliographical note

Keywords

Access to Document

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Projects

Cardiotonic steroids in patients with atrial fibrillation and heart failure: Quantification, functional effects and personalisation of digoxin therapy

H2020_COLLAB(IMI-JU)_BIGDATA@HEART

Optimising rate-control therapy in older patients with AF - a training fellowship and pilot study focused on improving quality of life (RATE-AF)

Cite this