QUADAS-2: A Revised Tool for the Quality Assessment of Diagnostic Accuracy Studies.

PF Whiting; AW Rutjes; ME Westwood; S Mallett; Jonathan Deeks; JB Reitsma; MM Leeflang; JA Sterne; PM Bossuyt

doi:10.7326/0003-4819-155-8-201110180-00009

QUADAS-2: A Revised Tool for the Quality Assessment of Diagnostic Accuracy Studies.

PF Whiting, AW Rutjes, ME Westwood, S Mallett, Jonathan Deeks, JB Reitsma, MM Leeflang, JA Sterne, PM Bossuyt

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Abstract

In 2003, the QUADAS tool for systematic reviews of diagnostic accuracy studies was developed. Experience, anecdotal reports, and feedback suggested areas for improvement; therefore, QUADAS-2 was developed. This tool comprises 4 domains: patient selection, index test, reference standard, and flow and timing. Each domain is assessed in terms of risk of bias, and the first 3 domains are also assessed in terms of concerns regarding applicability. Signalling questions are included to help judge risk of bias. The QUADAS-2 tool is applied in 4 phases: summarize the review question, tailor the tool and produce review-specific guidance, construct a flow diagram for the primary study, and judge bias and applicability. This tool will allow for more transparent rating of bias and applicability of primary diagnostic accuracy studies.

Original language	English
Pages (from-to)	529-536
Number of pages	8
Journal	Annals of internal medicine
Volume	155
Issue number	8
DOIs	https://doi.org/10.7326/0003-4819-155-8-201110180-00009
Publication status	Published - 18 Oct 2011

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title = "QUADAS-2: A Revised Tool for the Quality Assessment of Diagnostic Accuracy Studies.",

abstract = "In 2003, the QUADAS tool for systematic reviews of diagnostic accuracy studies was developed. Experience, anecdotal reports, and feedback suggested areas for improvement; therefore, QUADAS-2 was developed. This tool comprises 4 domains: patient selection, index test, reference standard, and flow and timing. Each domain is assessed in terms of risk of bias, and the first 3 domains are also assessed in terms of concerns regarding applicability. Signalling questions are included to help judge risk of bias. The QUADAS-2 tool is applied in 4 phases: summarize the review question, tailor the tool and produce review-specific guidance, construct a flow diagram for the primary study, and judge bias and applicability. This tool will allow for more transparent rating of bias and applicability of primary diagnostic accuracy studies.",

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AU - Leeflang, MM

AU - Sterne, JA

AU - Bossuyt, PM

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QUADAS-2: A Revised Tool for the Quality Assessment of Diagnostic Accuracy Studies.

Abstract

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