Pyruvate kinase, inflammation and periodontal disease

Melissa M. Grant

doi:10.3390/pathogens10070784

Pyruvate kinase, inflammation and periodontal disease

Melissa M. Grant

Dentistry

Research output: Contribution to journal › Review article › peer-review

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Abstract

Pyruvate kinase (PK) is the final and rate-limiting enzyme in glycolysis. It has four isoforms PKM1, PKM2, PKL and PKR. PK can form homo tetramers, dimers or monomers. The tetrameric form has the most catalytic activity; however, the dimeric form has non-canonical functions that contribute to the inflammatory response, wound healing and cellular crosstalk. This brief review explores these functions and speculates on their role in periodontal disease.

Original language	English
Article number	784
Pages (from-to)	784
Number of pages	6
Journal	Pathogens
Volume	10
Issue number	7
DOIs	https://doi.org/10.3390/pathogens10070784
Publication status	Published - 22 Jun 2021

Keywords

glycolysis
inflammation
pyruvate kinase
regulation

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10.3390/pathogens10070784Licence: Creative Commons: Attribution (CC BY)

GrantM2021PyruvateFinal published version, 573 KBLicence: Creative Commons: Attribution (CC BY)

Cite this

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AB - Pyruvate kinase (PK) is the final and rate-limiting enzyme in glycolysis. It has four isoforms PKM1, PKM2, PKL and PKR. PK can form homo tetramers, dimers or monomers. The tetrameric form has the most catalytic activity; however, the dimeric form has non-canonical functions that contribute to the inflammatory response, wound healing and cellular crosstalk. This brief review explores these functions and speculates on their role in periodontal disease.

KW - glycolysis

KW - inflammation

KW - pyruvate kinase

KW - regulation

UR - https://www.scopus.com/pages/publications/85114282286

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Pyruvate kinase, inflammation and periodontal disease

Abstract

Keywords

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