Pulsatile basal insulin secretion is driven by glycolytic oscillations

P. A. Fletcher; Isabella Marinelli; R. Bertram; L. S. Satin; A. S. Sherman

doi:10.1152/physiol.00044.2021

Pulsatile basal insulin secretion is driven by glycolytic oscillations

P. A. Fletcher, Isabella Marinelli, R. Bertram, L. S. Satin, A. S. Sherman

Metabolism and Systems Science

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Abstract

In fasted and fed states, blood insulin levels are oscillatory. While this phenomenon is well studied at high glucose levels, comparatively little is known about its origin under basal conditions. We propose a possible mechanism for basal insulin oscillations based on oscillations in glycolysis, demonstrated using an established mathematical model. At high glucose, this is superseded by a calcium-dependent mechanism.

Original language	English
Pages (from-to)	216-223
Number of pages	8
Journal	The Journal of Physiology
Volume	37
Issue number	4
Early online date	3 Jun 2022
DOIs	https://doi.org/10.1152/physiol.00044.2021
Publication status	Published - 1 Jul 2022

Keywords

bursting electrical activity
calcium
metabolism
pulsatile insulin secretion

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10.1152/physiol.00044.2021

FletcherP2022Pulsatile
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Cite this

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Pulsatile basal insulin secretion is driven by glycolytic oscillations

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Keywords

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