Pulsatile basal insulin secretion is driven by glycolytic oscillations

P. A. Fletcher, Isabella Marinelli, R. Bertram, L. S. Satin, A. S. Sherman

Research output: Contribution to journalArticlepeer-review

Abstract

In fasted and fed states, blood insulin levels are oscillatory. While this phenomenon is well studied at high glucose levels, comparatively little is known about its origin under basal conditions. We propose a possible mechanism for basal insulin oscillations based on oscillations in glycolysis, demonstrated using an established mathematical model. At high glucose, this is superseded by a calcium-dependent mechanism.
Original languageEnglish
Pages (from-to)216-223
Number of pages8
JournalThe Journal of Physiology
Volume37
Issue number4
Early online date3 Jun 2022
DOIs
Publication statusPublished - 1 Jul 2022

Keywords

  • bursting electrical activity
  • calcium
  • metabolism
  • pulsatile insulin secretion

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