Psychological symptomatology and impaired prepulse inhibition of the startle reflex are associated with cannabis-induced psychosis

Isabel Morales-Muñoz, Isabel Martínez-Gras, Guillermo Ponce, Javier de la Cruz, David Lora, Roberto Rodríguez-Jiménez, Rosa Jurado-Barba, Francisco Navarrete, María Salud García-Gutiérrez, Jorge Manzanares, Gabriel Rubio

Research output: Contribution to journalArticlepeer-review


BACKGROUND: Cannabis-induced psychotic disorder (CIPD) is a psychiatric disorder induced by cannabis consumption. The psychological and psychophysiological features of this disorder are still unknown. We aimed to examine the psychological, personality and psychophysiological features of patients with CIPD. This study is an analytical extension of our previously published data, which previously found prepulse inhibition (PPI) deficits in the CIPD group used in this current paper.

METHODS: We used a sample of 45 patients with CIPD. After 9 months of follow up, these patients were assessed with a Symptom Checklist-90-R (SCL-90-R) questionnaire of psychopathology, with the Eysenck Personality Questionnaire, and with a psychophysiological paradigm of inhibition of the startle reflex (PPI). These results were compared with a group of patients with schizophrenia and cannabis abuse (SCHZ) ( n = 54); patients with cannabis dependence (CD) ( n = 21); and healthy controls ( n = 50).

RESULTS: CIPD patients obtained significant higher scores in the SCL-90-R subscale of neuroticism. These patients showed PPI percentages similar to SCHZ patients within early attentional levels (30 ms). The variables with greater correlation, and that appeared in the CIPD group were interpersonal sensitivity, depression and phobia.

CONCLUSIONS: Neurotic symptomatology and difficulties in inhibition of the startle reflex might be risk factors for developing CIPD.

Original languageEnglish
Pages (from-to)1035-1045
Number of pages11
JournalJournal of Psychopharmacology
Issue number8
Publication statusPublished - Aug 2017


  • Adult
  • Case-Control Studies
  • Female
  • Humans
  • Male
  • Marijuana Abuse/complications
  • Neuroticism/drug effects
  • Personality Inventory
  • Prepulse Inhibition/physiology
  • Psychoses, Substance-Induced/complications
  • Reflex, Startle/physiology
  • Schizophrenia/physiopathology
  • Young Adult


Dive into the research topics of 'Psychological symptomatology and impaired prepulse inhibition of the startle reflex are associated with cannabis-induced psychosis'. Together they form a unique fingerprint.

Cite this