Proteomic investigations of in vitro and in vivo models of periodontal disease

Nurul Iman Binti Badlishah Sham, Sean Lewin, Melissa Grant

Research output: Contribution to journalReview articlepeer-review

3 Citations (Scopus)
194 Downloads (Pure)


Proteomics has currently been a developing field in periodontal diseases to obtain protein information of certain samples. Periodontal disease is an inflammatory disorder that attacks the teeth, connective tissues, and alveolar bone within the oral cavity. Proteomics information can provide proteins that are differentially expressed in diseased or healthy samples. This review provides insight into approaches researching single species, multi species, bacteria, non-human, and human models of periodontal disease for proteomics information. The approaches that have been taken include gel electrophoresis and qualitative and quantitative mass spectrometry. This review is carried out by extracting information about in vitro and in vivo studies of proteomics in models of periodontal diseases that have been carried out in the past two decades. The research has concentrated on a relatively small but well-known group of microorganisms. A wide range of models has been reviewed and conclusions across the breadth of these studies are presented in this review.

Original languageEnglish
Article number1900043
JournalPROTEOMICS-Clinical Applications
Early online date8 Sept 2019
Publication statusE-pub ahead of print - 8 Sept 2019


  • bacteria
  • model
  • periodontal disease
  • proteomics


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