Proteoglycans on endothelial cells present adhesion-inducing cytokines to leukocytes

Y Tanaka; D H Adams; S Shaw

doi:10.1016/0167-5699(93)90209-4

Proteoglycans on endothelial cells present adhesion-inducing cytokines to leukocytes

Y Tanaka
, D H Adams
, S Shaw

Research output: Contribution to journal › Article › peer-review

369 Citations (Scopus)

Abstract

Leukocyte recruitment from the blood circulation into tissue is essential for effective immune responses, and is, consequently, carefully regulated. In this article Yoshiya Tanaka and co-workers describe a model in which proteoglycans on the luminal surface of endothelium capture pro-adhesive cytokines. These cytokines provide the adhesion-inducing signal to particular leukocyte subsets which initiates their transmigration.

Original language	English
Pages (from-to)	111-5
Number of pages	5
Journal	Immunology Today
Volume	14
Issue number	3
DOIs	https://doi.org/10.1016/0167-5699(93)90209-4
Publication status	Published - Mar 1993

Keywords

Animals
Cell Adhesion
Cell Movement
Cytokines
Endothelium, Vascular
Glycosaminoglycans
Humans
Leukocytes
Models, Biological
Proteoglycans
Receptors, Lymphocyte Homing
Signal Transduction

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10.1016/0167-5699(93)90209-4

Cite this

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title = "Proteoglycans on endothelial cells present adhesion-inducing cytokines to leukocytes",

abstract = "Leukocyte recruitment from the blood circulation into tissue is essential for effective immune responses, and is, consequently, carefully regulated. In this article Yoshiya Tanaka and co-workers describe a model in which proteoglycans on the luminal surface of endothelium capture pro-adhesive cytokines. These cytokines provide the adhesion-inducing signal to particular leukocyte subsets which initiates their transmigration.",

keywords = "Animals, Cell Adhesion, Cell Movement, Cytokines, Endothelium, Vascular, Glycosaminoglycans, Humans, Leukocytes, Models, Biological, Proteoglycans, Receptors, Lymphocyte Homing, Signal Transduction",

author = "Y Tanaka and Adams, \{D H\} and S Shaw",

year = "1993",

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T1 - Proteoglycans on endothelial cells present adhesion-inducing cytokines to leukocytes

AU - Tanaka, Y

AU - Adams, D H

AU - Shaw, S

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N2 - Leukocyte recruitment from the blood circulation into tissue is essential for effective immune responses, and is, consequently, carefully regulated. In this article Yoshiya Tanaka and co-workers describe a model in which proteoglycans on the luminal surface of endothelium capture pro-adhesive cytokines. These cytokines provide the adhesion-inducing signal to particular leukocyte subsets which initiates their transmigration.

AB - Leukocyte recruitment from the blood circulation into tissue is essential for effective immune responses, and is, consequently, carefully regulated. In this article Yoshiya Tanaka and co-workers describe a model in which proteoglycans on the luminal surface of endothelium capture pro-adhesive cytokines. These cytokines provide the adhesion-inducing signal to particular leukocyte subsets which initiates their transmigration.

KW - Animals

KW - Cell Adhesion

KW - Cell Movement

KW - Cytokines

KW - Endothelium, Vascular

KW - Glycosaminoglycans

KW - Humans

KW - Leukocytes

KW - Models, Biological

KW - Proteoglycans

KW - Receptors, Lymphocyte Homing

KW - Signal Transduction

U2 - 10.1016/0167-5699(93)90209-4

DO - 10.1016/0167-5699(93)90209-4

M3 - Article

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VL - 14

SP - 111

EP - 115

JO - Immunology Today

JF - Immunology Today

IS - 3

ER -

Proteoglycans on endothelial cells present adhesion-inducing cytokines to leukocytes

Abstract

Keywords

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