Proteoglycans on endothelial cells present adhesion-inducing cytokines to leukocytes

Y Tanaka, D H Adams, S Shaw

Research output: Contribution to journalArticlepeer-review

369 Citations (Scopus)


Leukocyte recruitment from the blood circulation into tissue is essential for effective immune responses, and is, consequently, carefully regulated. In this article Yoshiya Tanaka and co-workers describe a model in which proteoglycans on the luminal surface of endothelium capture pro-adhesive cytokines. These cytokines provide the adhesion-inducing signal to particular leukocyte subsets which initiates their transmigration.
Original languageEnglish
Pages (from-to)111-5
Number of pages5
JournalImmunology Today
Issue number3
Publication statusPublished - Mar 1993


  • Animals
  • Cell Adhesion
  • Cell Movement
  • Cytokines
  • Endothelium, Vascular
  • Glycosaminoglycans
  • Humans
  • Leukocytes
  • Models, Biological
  • Proteoglycans
  • Receptors, Lymphocyte Homing
  • Signal Transduction


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