Abstract
Leukocyte recruitment from the blood circulation into tissue is essential for effective immune responses, and is, consequently, carefully regulated. In this article Yoshiya Tanaka and co-workers describe a model in which proteoglycans on the luminal surface of endothelium capture pro-adhesive cytokines. These cytokines provide the adhesion-inducing signal to particular leukocyte subsets which initiates their transmigration.
Original language | English |
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Pages (from-to) | 111-5 |
Number of pages | 5 |
Journal | Immunology Today |
Volume | 14 |
Issue number | 3 |
DOIs | |
Publication status | Published - Mar 1993 |
Keywords
- Animals
- Cell Adhesion
- Cell Movement
- Cytokines
- Endothelium, Vascular
- Glycosaminoglycans
- Humans
- Leukocytes
- Models, Biological
- Proteoglycans
- Receptors, Lymphocyte Homing
- Signal Transduction