Proteoglycans on endothelial cells present adhesion-inducing cytokines to leukocytes

Y Tanaka, D H Adams, S Shaw

Research output: Contribution to journalArticlepeer-review

369 Citations (Scopus)

Abstract

Leukocyte recruitment from the blood circulation into tissue is essential for effective immune responses, and is, consequently, carefully regulated. In this article Yoshiya Tanaka and co-workers describe a model in which proteoglycans on the luminal surface of endothelium capture pro-adhesive cytokines. These cytokines provide the adhesion-inducing signal to particular leukocyte subsets which initiates their transmigration.
Original languageEnglish
Pages (from-to)111-5
Number of pages5
JournalImmunology Today
Volume14
Issue number3
DOIs
Publication statusPublished - Mar 1993

Keywords

  • Animals
  • Cell Adhesion
  • Cell Movement
  • Cytokines
  • Endothelium, Vascular
  • Glycosaminoglycans
  • Humans
  • Leukocytes
  • Models, Biological
  • Proteoglycans
  • Receptors, Lymphocyte Homing
  • Signal Transduction

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