Protein sensing and discrimination using highly functionalised ruthenium(II) tris(bipyridyl) protein surface mimetics in an array format

Sarah H. Hewitt, Andrew J. Wilson*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

12 Citations (Scopus)

Abstract

Ruthenium(ii) tris(bipyridyl) protein surface mimetics are used in an array format to sense and discriminate proteins including therapeutically relevant targets, hDM2 and MCL-1, using linear discriminant analysis (LDA).

Original languageEnglish
Pages (from-to)12278-12281
Number of pages4
JournalChemical Communications
Volume53
Issue number91
DOIs
Publication statusPublished - 2017

Bibliographical note

Funding Information:
This work was supported by the Engineering and Physical Sciences Research Council [EP/L504993/1, EP/F039069, EP/F038712 and EP/N013573/1]. We would like to thank Kat Horner for synthesis of the NOXA-B peptide, Kirstin Spence for expression of hDM2 and MCL-1 and Georgina Pleasance for initial synthesis of complex 4.

Publisher Copyright:
© 2017 The Royal Society of Chemistry.

ASJC Scopus subject areas

  • Catalysis
  • Electronic, Optical and Magnetic Materials
  • Ceramics and Composites
  • General Chemistry
  • Surfaces, Coatings and Films
  • Metals and Alloys
  • Materials Chemistry

Fingerprint

Dive into the research topics of 'Protein sensing and discrimination using highly functionalised ruthenium(II) tris(bipyridyl) protein surface mimetics in an array format'. Together they form a unique fingerprint.

Cite this