Protein fibrillation and nanoparticle interactions: opportunities and challenges

Morteza Mahmoudi, Hamid R Kalhor, Sophie Laurent, Iseult Lynch

Research output: Contribution to journalArticlepeer-review

106 Citations (Scopus)


Due to their ultra-small size, nanoparticles (NPs) have distinct properties compared with the bulk form of the same materials. These properties are rapidly revolutionizing many areas of medicine and technology. NPs are recognized as promising and powerful tools to fight against the human brain diseases such as multiple sclerosis or Alzheimer's disease. In this review, after an introductory part on the nature of protein fibrillation and the existing approaches for its investigations, the effects of NPs on the fibrillation process have been considered. More specifically, the role of biophysicochemical properties of NPs, which define their affinity for protein monomers, unfolded monomers, oligomers, critical nuclei, and other prefibrillar states, together with their influence on protein fibrillation kinetics has been described in detail. In addition, current and possible-future strategies for controlling the desired effect of NPs and their corresponding effects on the conformational changes of the proteins, which have significant roles in the fibrillation process, have been presented.
Original languageEnglish
Pages (from-to)2570-88
Number of pages19
Issue number7
Publication statusPublished - 7 Apr 2013


Dive into the research topics of 'Protein fibrillation and nanoparticle interactions: opportunities and challenges'. Together they form a unique fingerprint.

Cite this