TY - JOUR
T1 - Prompt gamma neutron activation analysis facility for in vivo body composition in small animals
AU - Stamatelatos, IE
AU - Kasviki, K
AU - Green, Stuart
AU - Gainey, M
AU - Kalef-Ezra, J
AU - Beddoe, Alun
PY - 2004/1/1
Y1 - 2004/1/1
N2 - The design, calibration, dosimetry and performance evaluation of a prompt-gamma neutron activation analysis facility for in vivo body composition studies in small animals (i.e. rats or rabbits) is discussed. The system design was guided by Monte Carlo transport calculations using MCNP-4C code. A system was built and performance evaluation was made using a 185-GBq Pu-Be neutron source. Prompt-gamma rays produced by neutron capture reactions were detected by a combination of a NaI(Tl) scintillation and a HPGe semiconductor detectors. Nitrogen and chlorine were quantified by analysis of the 10.83-MeV and 6.11-MeV peaks, respectively. Appropriate corrections for the animal body size were determined. The facility described allows the in vivo determination of protein and extracellular space in sets of experimental animals.
AB - The design, calibration, dosimetry and performance evaluation of a prompt-gamma neutron activation analysis facility for in vivo body composition studies in small animals (i.e. rats or rabbits) is discussed. The system design was guided by Monte Carlo transport calculations using MCNP-4C code. A system was built and performance evaluation was made using a 185-GBq Pu-Be neutron source. Prompt-gamma rays produced by neutron capture reactions were detected by a combination of a NaI(Tl) scintillation and a HPGe semiconductor detectors. Nitrogen and chlorine were quantified by analysis of the 10.83-MeV and 6.11-MeV peaks, respectively. Appropriate corrections for the animal body size were determined. The facility described allows the in vivo determination of protein and extracellular space in sets of experimental animals.
UR - http://www.scopus.com/inward/record.url?scp=3042783348&partnerID=8YFLogxK
U2 - 10.1007/s00216-003-2460-6
DO - 10.1007/s00216-003-2460-6
M3 - Article
C2 - 14762643
SN - 1618-2650
VL - 379
SP - 192
EP - 197
JO - Analytical and Bioanalytical Chemistry
JF - Analytical and Bioanalytical Chemistry
ER -