Abstract
After an overdose of verapamil (2.4 g) in a 59-year-old man the apparent half-life of verapamil was prolonged (15 h). The most likely mechanism is rate-limiting absorption, although changes in clearance and volume of distribution may contribute. As the elimination half-life of verapamil is increased in overdose, therapy may have to be continued for longer than expected. Moreover since the half-life of absorption of verapamil in overdose may be prolonged, activated charcoal should be given in repeated doses, even if an ordinary-release formulation has been taken.
Original language | English |
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Pages (from-to) | 680-683 |
Number of pages | 4 |
Journal | British Journal of Clinical Pharmacology |
Volume | 39 |
Issue number | 6 |
Publication status | Published - Jun 1995 |