This review concentrates on the molecular pathology of the protein tau, including its expression in various regions of the brain. The role of post-translational modifications in fibrillogenesis is also discussed, particularly hyperphosphorylation and glycation. However, the initiating event that causes aberrant tau processing remains unclear.
|Number of pages||8|
|Publication status||Published - 1 Dec 2001|
- neurodegenerative disease
- progressive supranuclear palsy
- tau protein filaments
- oxidative stress