Abstract
This review concentrates on the molecular pathology of the protein tau, including its expression in various regions of the brain. The role of post-translational modifications in fibrillogenesis is also discussed, particularly hyperphosphorylation and glycation. However, the initiating event that causes aberrant tau processing remains unclear.
| Original language | English |
|---|---|
| Pages (from-to) | 427-34 |
| Number of pages | 8 |
| Journal | Molecular Pathology |
| Volume | 54 |
| Issue number | 6 |
| Publication status | Published - 1 Dec 2001 |
Keywords
- neurodegenerative disease
- progressive supranuclear palsy
- tau protein filaments
- oxidative stress