TY - JOUR
T1 - Programmable polymer-DNA hydrogels with dual input and multiscale responses
AU - Sicilia, G.
AU - Grainger-Boultby, C.
AU - Francini, N.
AU - Magnusson, J.P.
AU - Saeed, A.O.
AU - Fernández-Trillo, F.
AU - Spain, S.G.
AU - Alexander, C.
PY - 2014/2/1
Y1 - 2014/2/1
N2 - Combination switchable polymer-DNA hydrogels have been synthesized to respond to both a specific oligonucleotide recognition signal and a non-specific but biorelevant environmental trigger. The hydrogels exhibit rheological properties that can be modulated through interaction with complementary DNA strands and/or reduction. Furthermore, individual and combined oligonucleotide recognition and reduction responses allow control over pore sizes in the gel, enabling programmable release and transport of objects ranging from the nano- to micro-scale.
AB - Combination switchable polymer-DNA hydrogels have been synthesized to respond to both a specific oligonucleotide recognition signal and a non-specific but biorelevant environmental trigger. The hydrogels exhibit rheological properties that can be modulated through interaction with complementary DNA strands and/or reduction. Furthermore, individual and combined oligonucleotide recognition and reduction responses allow control over pore sizes in the gel, enabling programmable release and transport of objects ranging from the nano- to micro-scale.
UR - https://www.scopus.com/pages/publications/84891442129
U2 - 10.1039/c3bm60126a
DO - 10.1039/c3bm60126a
M3 - Article
AN - SCOPUS:84891442129
SN - 2047-4830
VL - 2
SP - 203
EP - 211
JO - Biomaterials Science
JF - Biomaterials Science
IS - 2
ER -