Programmable polymer-DNA hydrogels with dual input and multiscale responses

G. Sicilia, C. Grainger-Boultby, N. Francini, J.P. Magnusson, A.O. Saeed, F. Fernández-Trillo, S.G. Spain, C. Alexander

Research output: Contribution to journalArticlepeer-review

22 Citations (Scopus)


Combination switchable polymer-DNA hydrogels have been synthesized to respond to both a specific oligonucleotide recognition signal and a non-specific but biorelevant environmental trigger. The hydrogels exhibit rheological properties that can be modulated through interaction with complementary DNA strands and/or reduction. Furthermore, individual and combined oligonucleotide recognition and reduction responses allow control over pore sizes in the gel, enabling programmable release and transport of objects ranging from the nano- to micro-scale.
Original languageEnglish
Pages (from-to)203-211
Number of pages9
JournalBiomaterials Science
Issue number2
Publication statusPublished - 1 Feb 2014


Dive into the research topics of 'Programmable polymer-DNA hydrogels with dual input and multiscale responses'. Together they form a unique fingerprint.

Cite this