Prognostic value of TP53 codon 72 polymorphism in advanced gastric adenocarcinoma

Zun-Wu Zhang; Nicola J Laurence; Andrew Hollowood; Paul Newcomb; Moganaden Moorghen; Jyoti Gupta; Roger Feakins; Michael J G Farthing; Derek Alderson; Jeff Holly

Prognostic value of TP53 codon 72 polymorphism in advanced gastric adenocarcinoma

Zun-Wu Zhang, Nicola J Laurence, Andrew Hollowood, Paul Newcomb, Moganaden Moorghen, Jyoti Gupta, Roger Feakins, Michael J G Farthing, Derek Alderson, Jeff Holly

Cancer and Genomic Sciences

Research output: Contribution to journal › Article › peer-review

23 Citations (Scopus)

Abstract

A common polymorphism of the tumor suppressor gene TP53 at codon 72 has been associated with human cancer susceptibility. The prognostic role of the polymorphism was assessed in 102 patients with advanced gastric adenocarcinoma. Experimental Design: We followed up 102 consecutive Caucasian patients with advanced gastric adenocarcinoma for >5 years and determined the status of the TP53 codon 72 polymorphism in DNA samples extracted from archived gastric tissues.

Original language	English
Pages (from-to)	131-5
Number of pages	5
Journal	Clinical Cancer Research
Volume	10
Issue number	1 Pt 1
Publication status	Published - 2004

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@article{3cee6d002b51442b8673a37967d07a12,

title = "Prognostic value of TP53 codon 72 polymorphism in advanced gastric adenocarcinoma",

abstract = "A common polymorphism of the tumor suppressor gene TP53 at codon 72 has been associated with human cancer susceptibility. The prognostic role of the polymorphism was assessed in 102 patients with advanced gastric adenocarcinoma. Experimental Design: We followed up 102 consecutive Caucasian patients with advanced gastric adenocarcinoma for >5 years and determined the status of the TP53 codon 72 polymorphism in DNA samples extracted from archived gastric tissues.",

author = "Zun-Wu Zhang and Laurence, {Nicola J} and Andrew Hollowood and Paul Newcomb and Moganaden Moorghen and Jyoti Gupta and Roger Feakins and Farthing, {Michael J G} and Derek Alderson and Jeff Holly",

year = "2004",

language = "English",

volume = "10",

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journal = "Clinical Cancer Research",

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publisher = "American Association for Cancer Research",

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T1 - Prognostic value of TP53 codon 72 polymorphism in advanced gastric adenocarcinoma

AU - Zhang, Zun-Wu

AU - Laurence, Nicola J

AU - Hollowood, Andrew

AU - Newcomb, Paul

AU - Moorghen, Moganaden

AU - Gupta, Jyoti

AU - Feakins, Roger

AU - Farthing, Michael J G

AU - Alderson, Derek

AU - Holly, Jeff

PY - 2004

Y1 - 2004

N2 - A common polymorphism of the tumor suppressor gene TP53 at codon 72 has been associated with human cancer susceptibility. The prognostic role of the polymorphism was assessed in 102 patients with advanced gastric adenocarcinoma. Experimental Design: We followed up 102 consecutive Caucasian patients with advanced gastric adenocarcinoma for >5 years and determined the status of the TP53 codon 72 polymorphism in DNA samples extracted from archived gastric tissues.

AB - A common polymorphism of the tumor suppressor gene TP53 at codon 72 has been associated with human cancer susceptibility. The prognostic role of the polymorphism was assessed in 102 patients with advanced gastric adenocarcinoma. Experimental Design: We followed up 102 consecutive Caucasian patients with advanced gastric adenocarcinoma for >5 years and determined the status of the TP53 codon 72 polymorphism in DNA samples extracted from archived gastric tissues.

M3 - Article

C2 - 14734461

SN - 1078-0432

VL - 10

SP - 131

EP - 135

JO - Clinical Cancer Research

JF - Clinical Cancer Research

IS - 1 Pt 1

ER -

Prognostic value of TP53 codon 72 polymorphism in advanced gastric adenocarcinoma

Abstract

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