Probing the mechanism of the Mycobacterium tuberculosis β-ketoacyl-acyl Carrier Protein synthase III mtFabH: Factors influencing catalysis and substrate specificity

Medicine & Life Sciences

• holo-(acyl-carrier-protein) synthase 100%
• Type II Fatty Acid Synthase 74%
• Acyl Coenzyme A 71%
• Catalysis 63%
• meromycolic acids 63%
• Acyl Carrier Protein 62%
• Substrate Specificity 59%
• Glycogen Synthase 53%
• Fatty Acid Synthases 52%
• Mycobacterium tuberculosis 51%
• Fatty Acids 45%
• Decarboxylation 37%
• E coli acpP protein 27%
• 3-ketoacyl-acyl carrier protein synthase III 27%
• Type I Fatty Acid Synthase 25%
• Mycolic Acids 20%
• Hydroxy Acids 19%
• Mutation 14%
• Enzymes 14%
• Cell Wall 13%
• Escherichia coli 9%
• Water 8%
• In Vitro Techniques 5%

Chemistry

• Fatty Acid 42%
• Catalysis 34%
• Acyl-CoA 27%
• Protein 21%
• Transacylation 16%
• Acyl-Carrier Protein 15%
• Decarboxylation 10%
• Substitution Reaction 10%
• Mutation 8%
• Mycolic Acid 8%
• Condensation 7%
• Deprotonation 4%
• Acid 3%
• Length 3%
• Molecule 1%