Primary hepatocytes as targets for hepatitis C virus replication.

Michelle Farquhar, Jane McKeating

Research output: Contribution to journalArticle

23 Citations (Scopus)
101 Downloads (Pure)

Abstract

Much of our current understanding of hepatitis C virus (HCV) replication has hailed from the use of a small number of cloned viral genomes and transformed hepatoma cell lines. Recent evidence suggests that lipoproteins play a key role in the HCV life cycle and virus particles derived from the sera of infected patients exist in association with host lipoproteins. This report will review the literature on HCV replication in primary hepatocytes and transformed cell lines, focusing largely on host factors defining particle entry.
Original languageEnglish
Pages (from-to)849-54
Number of pages6
JournalJournal of viral hepatitis
Volume15
Issue number12
DOIs
Publication statusPublished - 1 Dec 2008

Keywords

  • lipoproteins
  • receptors
  • hepatocyte
  • internalization
  • hepatitis C

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