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Abstract
Previous laboratory studies have implicated triclosan as a possible selective force driving resistance to multiple antibiotics and have identified a number of triclosan resistance mechanisms in Salmonella enterica. The aim of this work was to determine the prevalence of decreased susceptibility to triclosan in a panel of human and animal isolates of S. enterica and to identify the mechanisms of triclosan resistance in these strains. Over 400 animal and human isolates of non-typhoidal Salmonella were screened for decreased susceptibility to triclosan and a panel of antibiotics. The prevalence of decreased susceptibility to triclosan was ca. 4%. Of the isolates with decreased triclosan susceptibility, 56% were multidrug-resistant (MDR) compared with 12% of triclosan-sensitive isolates. MDR and triclosan-resistant strains showed increased efflux activity compared with strains with reduced susceptibility to triclosan alone. No high-level triclosan resistance was seen in this panel of isolates. A reservoir of strains with low-level decreased triclosan susceptibility is present in animals and humans. These isolates are MDR as a result of generic mechanisms of antimicrobial resistance and do not carry specific mutations within fabI. (C) 2010 Elsevier B.V. and the International Society of Chemotherapy. All rights reserved.
Original language | English |
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Pages (from-to) | 247-251 |
Number of pages | 5 |
Journal | International Journal of Antimicrobial Agents |
Volume | 36 |
Issue number | 3 |
DOIs | |
Publication status | Published - 1 Sept 2010 |
Keywords
- Salmonellosis
- Efflux
- Biocides
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Dive into the research topics of 'Prevalence of decreased susceptibility to triclosan in Salmonella enterica isolates from animals and humans and association with multiple drug resistance'. Together they form a unique fingerprint.Projects
- 1 Finished
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David Phillips Fellowship : Characterisation of Triclosan Resistance in Salmonella Enterica Serovar Typhimurium
Webber, M. (Principal Investigator)
Biotechnology & Biological Sciences Research Council
1/01/07 → 30/12/11
Project: Research Councils