Prevalence and inter-relationship of different Doppler measures of dyssynchrony in patients with heart failure and prolonged QRS: a report from CARE-HF

M Edner; Y Kim; K Hansen; H Nissen; G Espersen; K La Rosee; F Maru; Nick Freemantle; J Cleland; P Sogaard

doi:10.1186/1476-7120-7-1

Prevalence and inter-relationship of different Doppler measures of dyssynchrony in patients with heart failure and prolonged QRS: a report from CARE-HF

M Edner, Y Kim, K Hansen, H Nissen, G Espersen, K La Rosee, F Maru, Nick Freemantle, J Cleland, P Sogaard

Research output: Contribution to journal › Article

4 Citations (Scopus)

Abstract

BACKGROUND: Cardiac resynchronisation therapy (CRT) improves mortality and morbidity in heart failure patients with wide QRS. Observational studies suggest that patients having more left ventricular dyssynchrony pre-implantation obtain greater benefit on ventricular function and symptoms with CRT. AIM: To provide an analysis of the prevalence and type of dyssynchrony in patients included in the CARE-HF trial. METHODS: 100 patients 67 (58 to 71) years were examined with echocardiography including tissue doppler imaging before receiving a CRT-pacemaker. Atrio-ventricular dyssynchrony (LVFT/RR) was defined as left ventricular filling time 40 ms. Intra-ventricular (regional) dyssynchrony in a 16-segment model was expressed either as a delayed longitudinal contraction (DLC) during the postsystolic phase or by tissue synchronisation imaging (TSI) with a predefined time-difference in systolic maximal velocities >85 ms. RESULTS: LVFT/RR was present in 34% and IVMD in 60% of patients while intra-ventricular dyssynchrony was present in 85% (DLC) and 86% (TSI) with a high agreement between the measures (Kappascore 0.86-1.00), indicating the methods being interchangeable. Patients with cardiomyopathy (53%) were more likely to have LVFT/RR

Original language	English
Pages (from-to)	1-
Journal	Cardiovascular Ultrasound
Volume	7
Issue number	1
DOIs	https://doi.org/10.1186/1476-7120-7-1
Publication status	Published - 1 Jan 2009

Access to Document

10.1186/1476-7120-7-1

Cite this

@article{74940be1fffb496784a1c5c02b1127e2,

title = "Prevalence and inter-relationship of different Doppler measures of dyssynchrony in patients with heart failure and prolonged QRS: a report from CARE-HF",

abstract = "BACKGROUND: Cardiac resynchronisation therapy (CRT) improves mortality and morbidity in heart failure patients with wide QRS. Observational studies suggest that patients having more left ventricular dyssynchrony pre-implantation obtain greater benefit on ventricular function and symptoms with CRT. AIM: To provide an analysis of the prevalence and type of dyssynchrony in patients included in the CARE-HF trial. METHODS: 100 patients 67 (58 to 71) years were examined with echocardiography including tissue doppler imaging before receiving a CRT-pacemaker. Atrio-ventricular dyssynchrony (LVFT/RR) was defined as left ventricular filling time 40 ms. Intra-ventricular (regional) dyssynchrony in a 16-segment model was expressed either as a delayed longitudinal contraction (DLC) during the postsystolic phase or by tissue synchronisation imaging (TSI) with a predefined time-difference in systolic maximal velocities >85 ms. RESULTS: LVFT/RR was present in 34% and IVMD in 60% of patients while intra-ventricular dyssynchrony was present in 85% (DLC) and 86% (TSI) with a high agreement between the measures (Kappascore 0.86-1.00), indicating the methods being interchangeable. Patients with cardiomyopathy (53%) were more likely to have LVFT/RR ",

author = "M Edner and Y Kim and K Hansen and H Nissen and G Espersen and {La Rosee}, K and F Maru and Nick Freemantle and J Cleland and P Sogaard",

year = "2009",

month = jan,

day = "1",

doi = "10.1186/1476-7120-7-1",

language = "English",

volume = "7",

pages = "1--",

journal = "Cardiovascular Ultrasound",

publisher = "Springer",

number = "1",

}

TY - JOUR

T1 - Prevalence and inter-relationship of different Doppler measures of dyssynchrony in patients with heart failure and prolonged QRS: a report from CARE-HF

AU - Edner, M

AU - Kim, Y

AU - Hansen, K

AU - Nissen, H

AU - Espersen, G

AU - La Rosee, K

AU - Maru, F

AU - Freemantle, Nick

AU - Cleland, J

AU - Sogaard, P

PY - 2009/1/1

Y1 - 2009/1/1

N2 - BACKGROUND: Cardiac resynchronisation therapy (CRT) improves mortality and morbidity in heart failure patients with wide QRS. Observational studies suggest that patients having more left ventricular dyssynchrony pre-implantation obtain greater benefit on ventricular function and symptoms with CRT. AIM: To provide an analysis of the prevalence and type of dyssynchrony in patients included in the CARE-HF trial. METHODS: 100 patients 67 (58 to 71) years were examined with echocardiography including tissue doppler imaging before receiving a CRT-pacemaker. Atrio-ventricular dyssynchrony (LVFT/RR) was defined as left ventricular filling time 40 ms. Intra-ventricular (regional) dyssynchrony in a 16-segment model was expressed either as a delayed longitudinal contraction (DLC) during the postsystolic phase or by tissue synchronisation imaging (TSI) with a predefined time-difference in systolic maximal velocities >85 ms. RESULTS: LVFT/RR was present in 34% and IVMD in 60% of patients while intra-ventricular dyssynchrony was present in 85% (DLC) and 86% (TSI) with a high agreement between the measures (Kappascore 0.86-1.00), indicating the methods being interchangeable. Patients with cardiomyopathy (53%) were more likely to have LVFT/RR

AB - BACKGROUND: Cardiac resynchronisation therapy (CRT) improves mortality and morbidity in heart failure patients with wide QRS. Observational studies suggest that patients having more left ventricular dyssynchrony pre-implantation obtain greater benefit on ventricular function and symptoms with CRT. AIM: To provide an analysis of the prevalence and type of dyssynchrony in patients included in the CARE-HF trial. METHODS: 100 patients 67 (58 to 71) years were examined with echocardiography including tissue doppler imaging before receiving a CRT-pacemaker. Atrio-ventricular dyssynchrony (LVFT/RR) was defined as left ventricular filling time 40 ms. Intra-ventricular (regional) dyssynchrony in a 16-segment model was expressed either as a delayed longitudinal contraction (DLC) during the postsystolic phase or by tissue synchronisation imaging (TSI) with a predefined time-difference in systolic maximal velocities >85 ms. RESULTS: LVFT/RR was present in 34% and IVMD in 60% of patients while intra-ventricular dyssynchrony was present in 85% (DLC) and 86% (TSI) with a high agreement between the measures (Kappascore 0.86-1.00), indicating the methods being interchangeable. Patients with cardiomyopathy (53%) were more likely to have LVFT/RR

U2 - 10.1186/1476-7120-7-1

DO - 10.1186/1476-7120-7-1

M3 - Article

C2 - 19128462

VL - 7

SP - 1-

JO - Cardiovascular Ultrasound

JF - Cardiovascular Ultrasound

IS - 1

ER -

Prevalence and inter-relationship of different Doppler measures of dyssynchrony in patients with heart failure and prolonged QRS: a report from CARE-HF

Abstract

Access to Document

Fingerprint

Cite this