Prevalence and antimicrobial susceptibilities of Acinetobacter baumannii and non-baumannii Acinetobacters from Terengganu, Malaysia and their carriage of carbapenemase genes

Farahiyah Mohd Rani, Nor Iza A Rahman, Salwani Ismail, Fatimah Haslina Abdullah, Norlela Othman, Ahmed Ghazi Alattraqchi, David W. Cleary, Stuart C. Clarke, Chew Chieng Yeo

Research output: Contribution to journalArticlepeer-review

Abstract

A total of 153 non-repeat Acinetobacter spp. clinical isolates obtained in 2015 from Hospital Sultanah Nur Zahirah (HSNZ) in Terengganu, Malaysia, were characterized. Identification of the isolates at species level was performed by ribosomal DNA restriction analysis (ARDRA) followed by sequencing of the rpoB gene. The majority of the isolates (n=128; 83.7 %) were A. baumannii while the rest were identified as A. nosocomialis (n=16), A. calcoaceticus (n=5), A. soli (n=2), A. berezeniae (n=1) and A. variabilis (n=1). Multidrug resistance (MDR) was most prevalent in A. baumannnii (66.4 %) whereas only one non-baumannii isolate (A. nosocomialis) was MDR. The blaOXA-23 gene was the predominant acquired carbapenemase gene (56.2 %) and was significantly associated (P
Original languageEnglish
Pages (from-to)1538-1543
Number of pages6
JournalJournal of Medical Microbiology
Volume67
Issue number11
DOIs
Publication statusPublished - 1 Nov 2018

Keywords

  • Acinetobacter baumannii
  • beta-lactamases
  • carbapenem resistance
  • multidrug resistance
  • non-baumannii Acinetobacter

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