Presence and severity of non-alcoholic fatty liver disease in a large prospective primary care cohort

Matthew Armstrong; Diarmaid Houlihan; Louise Bentham; Jean Shaw; Robert Cramb; S Olliff; Paramjit Gill; James Neuberger; Richard Lilford; Philip Newsome

doi:10.1016/j.jhep.2011.03.020

Presence and severity of non-alcoholic fatty liver disease in a large prospective primary care cohort

Matthew Armstrong, Diarmaid Houlihan, Louise Bentham, Jean Shaw, Robert Cramb, S Olliff, Paramjit Gill, James Neuberger, Richard Lilford, Philip Newsome

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Abstract

Background & Aims: Non-alcoholic fatty liver disease (NAFLD) is a common cause of abnormal LFTs in primary care, but there are no data defining its contribution nor reporting the range of NAFLD severity in this setting. This study seeks to calculate the range of disease severity of NAFLD in a primary care setting. Methods: Adult patients with incidental abnormal LFTs, in the absence of a previous history, or current symptoms/ signs of liver disease were prospectively recruited from eight primary care practices in Birmingham. NAFLD was diagnosed as fatty liver on ultrasound, negative serological liver aetiology screen, and alcohol consumption 0.676) suggesting the presence of advanced liver fibrosis was found in 7.6% of NAFLD subjects, whereas 57.2% of NAFLD patients had a low NFS (

Original language	English
Pages (from-to)	234-240
Number of pages	7
Journal	Journal of Hepatology
Volume	56
Issue number	1
DOIs	https://doi.org/10.1016/j.jhep.2011.03.020
Publication status	Published - 1 Jan 2012

Keywords

Non-alcoholic fatty liver
Fibrosis
Liver function test
Primary care

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10.1016/j.jhep.2011.03.020

Mesenchymal Stem Cell Homing to the Chronically Injured Liver
Newsome, P. (Principal Investigator) & Frampton, J. (Co-Investigator)
Medical Research Council
3/08/09 → 2/08/12
Project: Research Councils

Cite this

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title = "Presence and severity of non-alcoholic fatty liver disease in a large prospective primary care cohort",

abstract = "Background & Aims: Non-alcoholic fatty liver disease (NAFLD) is a common cause of abnormal LFTs in primary care, but there are no data defining its contribution nor reporting the range of NAFLD severity in this setting. This study seeks to calculate the range of disease severity of NAFLD in a primary care setting. Methods: Adult patients with incidental abnormal LFTs, in the absence of a previous history, or current symptoms/ signs of liver disease were prospectively recruited from eight primary care practices in Birmingham. NAFLD was diagnosed as fatty liver on ultrasound, negative serological liver aetiology screen, and alcohol consumption 0.676) suggesting the presence of advanced liver fibrosis was found in 7.6% of NAFLD subjects, whereas 57.2% of NAFLD patients had a low NFS (",

keywords = "Non-alcoholic fatty liver, Fibrosis, Liver function test, Primary care",

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T1 - Presence and severity of non-alcoholic fatty liver disease in a large prospective primary care cohort

AU - Armstrong, Matthew

AU - Houlihan, Diarmaid

AU - Bentham, Louise

AU - Shaw, Jean

AU - Cramb, Robert

AU - Olliff, S

AU - Gill, Paramjit

AU - Neuberger, James

AU - Lilford, Richard

AU - Newsome, Philip

PY - 2012/1/1

Y1 - 2012/1/1

N2 - Background & Aims: Non-alcoholic fatty liver disease (NAFLD) is a common cause of abnormal LFTs in primary care, but there are no data defining its contribution nor reporting the range of NAFLD severity in this setting. This study seeks to calculate the range of disease severity of NAFLD in a primary care setting. Methods: Adult patients with incidental abnormal LFTs, in the absence of a previous history, or current symptoms/ signs of liver disease were prospectively recruited from eight primary care practices in Birmingham. NAFLD was diagnosed as fatty liver on ultrasound, negative serological liver aetiology screen, and alcohol consumption 0.676) suggesting the presence of advanced liver fibrosis was found in 7.6% of NAFLD subjects, whereas 57.2% of NAFLD patients had a low NFS (

AB - Background & Aims: Non-alcoholic fatty liver disease (NAFLD) is a common cause of abnormal LFTs in primary care, but there are no data defining its contribution nor reporting the range of NAFLD severity in this setting. This study seeks to calculate the range of disease severity of NAFLD in a primary care setting. Methods: Adult patients with incidental abnormal LFTs, in the absence of a previous history, or current symptoms/ signs of liver disease were prospectively recruited from eight primary care practices in Birmingham. NAFLD was diagnosed as fatty liver on ultrasound, negative serological liver aetiology screen, and alcohol consumption 0.676) suggesting the presence of advanced liver fibrosis was found in 7.6% of NAFLD subjects, whereas 57.2% of NAFLD patients had a low NFS (

KW - Non-alcoholic fatty liver

KW - Fibrosis

KW - Liver function test

KW - Primary care

U2 - 10.1016/j.jhep.2011.03.020

DO - 10.1016/j.jhep.2011.03.020

M3 - Article

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EP - 240

JO - Journal of Hepatology

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Presence and severity of non-alcoholic fatty liver disease in a large prospective primary care cohort

Abstract

Keywords

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Mesenchymal Stem Cell Homing to the Chronically Injured Liver

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