Preparation of multifunctional nanoparticles and their assemblies

Sarah A. McCarthy; Gemma Louise Davies; Yurii K. Gun'ko

doi:10.1038/nprot.2012.082

Preparation of multifunctional nanoparticles and their assemblies

Sarah A. McCarthy, Gemma Louise Davies, Yurii K. Gun'ko^*

^*Corresponding author for this work

Chemistry

Research output: Contribution to journal › Article › peer-review

103 Citations (Scopus)

Abstract

This article describes the synthesis of multifunctional nanoparticulate systems and a range of organic reactions for modifying the surface functionalities of these particles and their composites. The reactions include surface silanization, amine-azide conversion, azide-alkyne 'click' chemistry, thiol and amine click chemistry and amide coupling. In addition, we discuss a number of relevant nanoparticle preparations to exemplify the interrelationship of these reactions. This system can readily be adapted to produce a wide range of composites with different features, such as fluorescence, magnetism, plasmon resonance and multiple biofunctionalities.

Original language	English
Pages (from-to)	1677-1693
Number of pages	17
Journal	Nature protocols
Volume	7
Issue number	9
DOIs	https://doi.org/10.1038/nprot.2012.082
Publication status	Published - Sept 2012

Bibliographical note

Funding Information:
acKnowleDGMents We are grateful to FP7 EU NAMDIATREAM (nanotechnological toolkits for multimodal disease diagnostics and treatment monitoring) for providing financial support.

ASJC Scopus subject areas

General Biochemistry,Genetics and Molecular Biology

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10.1038/nprot.2012.082

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author = "McCarthy, {Sarah A.} and Davies, {Gemma Louise} and Gun'ko, {Yurii K.}",

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AB - This article describes the synthesis of multifunctional nanoparticulate systems and a range of organic reactions for modifying the surface functionalities of these particles and their composites. The reactions include surface silanization, amine-azide conversion, azide-alkyne 'click' chemistry, thiol and amine click chemistry and amide coupling. In addition, we discuss a number of relevant nanoparticle preparations to exemplify the interrelationship of these reactions. This system can readily be adapted to produce a wide range of composites with different features, such as fluorescence, magnetism, plasmon resonance and multiple biofunctionalities.

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Preparation of multifunctional nanoparticles and their assemblies

Abstract

Bibliographical note

ASJC Scopus subject areas

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