Preparation of an amorphous sodium furosemide salt improves solubility and dissolution rate and leads to a faster T_max after oral dosing to rats

Chemistry

• Furosemide 100%
• Tmax 99%
• Dissolution 53%
• Amorphous Material 49%
• Solubility 45%
• Sodium Atom 45%
• Acid 13%
• Sodium Salt 5%
• Humidity 5%
• Devitrification 4%
• Peak Plasma Concentration 3%
• Aqueous Solvent 3%
• Fourier Transform Infrared Spectroscopy 3%
• Dosage Form 2%
• Bioavailability 2%
• Spray 2%
• Glass Transition Temperature 2%
• Powder X-Ray Diffraction 2%
• Differential Scanning Calorimetry 2%
• Surfactant 1%
• Buffer Solution 1%
• Methanol 1%
• Solvent 1%
• Amount 1%

Medicine & Life Sciences

• Furosemide 83%
• Solubility 72%
• Salts 63%
• Sodium 60%
• Acids 54%
• Humidity 12%
• Fourier Transform Infrared Spectroscopy 12%
• Powder Diffraction 8%
• Sodium Hydroxide 8%
• Transition Temperature 7%
• Vitrification 7%
• Differential Scanning Calorimetry 6%
• X-Ray Diffraction 6%
• Dosage Forms 6%
• Surface-Active Agents 5%
• Methanol 5%
• Buffers 5%
• Biological Availability 5%
• Area Under Curve 4%
• Stomach 3%
• In Vitro Techniques 2%