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Abstract
Hydroxyapatite (HA) substituted with 2 mol% Sr, 10 mol% Mg, and 2 mol% Zn were precipitated under identical alkaline conditions (pH 11) at 20 C from an aqueous solution. As-synthesised materials were confirmed to be phase pure by XRD and samples prepared in air contained surface adsorbed CO2 as observed by FTIR. SEM studies revealed a globular morphology and agglomeration behaviour, typical of precipitated nHA. EDS spectra confirmed nominal compositions and substitution of Sr, Mg and Zn. At the levels investigated cationic doping was not found to radically influence particle morphology. An indication of the potential in-vivo bioactivity of samples was achieved by analysing samples immersed in SBF for up to 28 days by interferometry and complementary SEM micrographs. Furthermore, a live/dead assay was used and confirmed the viability of seeded MC3T3 osteoblast precursor cells on HA and substituted HA substrates up to 7 days of culture.
Original language | English |
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Pages (from-to) | 106-114 |
Number of pages | 9 |
Journal | Materials Science and Engineering C |
Volume | 35 |
Issue number | 1 |
DOIs | |
Publication status | Published - 2014 |
Keywords
- Aqueous precipitation
- Bioceramics
- Osteoblasts
- Simulated body fluid
- Substituted hydroxyapatite
ASJC Scopus subject areas
- General Materials Science
- Condensed Matter Physics
- Mechanical Engineering
- Mechanics of Materials
- General Medicine
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Dive into the research topics of 'Preparation and characterisation of nanophase Sr, Mg, and Zn substituted hydroxyapatite by aqueous precipitation'. Together they form a unique fingerprint.Projects
- 1 Finished
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Novel Implant Design and Manufacture with Embedded Therapeutics
Grover, L. (Principal Investigator), Addison, O. (Co-Investigator), Attallah, M. (Co-Investigator) & Shepherd, D. (Co-Investigator)
Engineering & Physical Science Research Council
19/06/14 → 18/06/17
Project: Research Councils