Prejunctional and postjunctional actions of heptanol and 18β-glycyrretinic acid in the rodent vas deferens

F Rahman, R Manchanda, Keith Brain

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Abstract

Heptanol and 18 beta-glycyrrhetinic acid (18 beta GA) block gap junctions, but have other actions on transmitter release that have not been characterised. This study investigates the prejunctional and postjunctional effects of these compounds in guinea pig and mouse vas deferens using intracellular electrophysiological recording and confocal Ca(2+) imaging of sympathetic nerve terminals. In mice, heptanol (2 mM) reversibly decreased the amplitude of purinergic excitatory junction potentials (EJPs; 52+/-5%, P
Original languageEnglish
Pages (from-to)69-75
Number of pages7
JournalAutonomic Neuroscience
Volume148
Issue number1-2
DOIs
Publication statusPublished - 15 Jun 2009

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