TY - JOUR
T1 - Preincubation of pneumococci with β-Lactams alone or combined with livofloxacin prevents quinolone-induced resistance without increasing intracellular levels of levofloxacin
AU - Cottagnoud, P
AU - Johnson, Margaret
AU - Cottagnoud, M
AU - Piddock, Laura
PY - 2005/8/1
Y1 - 2005/8/1
N2 - Preincubation of pneumococci with sub-MIC concentrations of ceftriaxone (1/16 x MIC), cefotaxime (1/8 x MIC), and meropenem (1/4 x MIC) alone or combined with levofloxacin (1/8 x MIC) over 6 h Prevents the emergence of levofloxacin-resistant mutants after 96 h of incubation but does not affect the intracellular accumulation of levofloxacin in two penicillin-resistant pneumococcal strains, suggesting a link between the mechanism of action of beta-lactams and the emergence of quinolone-induced resistance in pneumococci.
AB - Preincubation of pneumococci with sub-MIC concentrations of ceftriaxone (1/16 x MIC), cefotaxime (1/8 x MIC), and meropenem (1/4 x MIC) alone or combined with levofloxacin (1/8 x MIC) over 6 h Prevents the emergence of levofloxacin-resistant mutants after 96 h of incubation but does not affect the intracellular accumulation of levofloxacin in two penicillin-resistant pneumococcal strains, suggesting a link between the mechanism of action of beta-lactams and the emergence of quinolone-induced resistance in pneumococci.
UR - http://www.scopus.com/inward/record.url?scp=23044482239&partnerID=8YFLogxK
U2 - 10.1128/AAC.49.8.3517-3519.2005
DO - 10.1128/AAC.49.8.3517-3519.2005
M3 - Article
VL - 49
SP - 3517
EP - 3519
JO - Antimicrobial Agents and Chemotherapy
JF - Antimicrobial Agents and Chemotherapy
ER -