Pregnancy in women with Type 2 diabetes: 12 years outcome data 1990-2002

Fidelma Dunne, P Brydon, K Smith, H Gee

    Research output: Contribution to journalArticle

    166 Citations (Scopus)

    Abstract

    Aim Twelve years' outcome analysis of pregnancies in women with Type 2 diabetes in a multiethnic geographically defined area. Methods Information about 182 women delivered between 1990 and 2002 was ascertained from a regional computerized database. The main outcome measures were rates of miscarriage, stillbirth, neonatal/postnatal deaths, congenital malformations, birth weight, mode of delivery, and neonatal unit care as well as maternal morbidities of polyhydramnios, postpartum haemorrhage, pregnancy-induced hypertension/pre-eclampsia. Results Among 182 singleton pregnancies, 161 (88%) resulted in a live outcome. There were 16 (8.8%) spontaneous miscarriages, two (1.2%) stillbirths, and three (1.6%) terminations. Congenital malformations occurred in 18 pregnancies (99/1000). There were two early and one late neonatal deaths and two further deaths in the postnatal period. Twenty-eight percent of infants were large for gestational age, with 15 (9.3%) greater than 4 kg. Fifty-three percent were delivered by caesarean section and 68 (37%) required admission to neonatal unit (NNU) care. Hypertension/pre-eclampsia was two times, polyhydramnios three times, and postpartum haemorrhage six times more common than in nondiabetic women. Conclusions Women with Type 2 diabetes have a less satisfactory pregnancy outcome compared with the general population. Infants have a two-fold greater risk of stillbirth, a 2.5-fold greater risk of a perinatal mortality, a 3.5-fold greater risk of death within the first month and a six-fold greater risk of death up to 1 year compared with regional/national figures. They have an 11 times greater risk of a congenital malformation. We need to develop better educational and screening strategies if we are to improve.
    Original languageEnglish
    Pages (from-to)734-738
    Number of pages5
    JournalDiabetic Medicine
    Volume20
    Issue number9
    DOIs
    Publication statusPublished - 1 Sep 2003

    Keywords

    • congenital malformations
    • perinatal mortality
    • pregnancy
    • Type 2 diabetes
    • maternal morbidity

    Fingerprint

    Dive into the research topics of 'Pregnancy in women with Type 2 diabetes: 12 years outcome data 1990-2002'. Together they form a unique fingerprint.

    Cite this