Predictors during childhood of future health-related quality of life in adults with Gilles de la Tourette syndrome

Andrea E Cavanna, Kate David, Michael Orth, Mary M Robertson

Research output: Contribution to journalArticlepeer-review

44 Citations (Scopus)


BACKGROUND: Gilles de la Tourette syndrome (GTS) is a chronic neurodevelopmental disorder characterised by multiple motor and phonic tics and behavioural problems. Patients with GTS of all ages often report a poor health-related quality of life (HR-QOL). The diagnosis of GTS is usually established in childhood but little is known about factors that predict the long-term well-being of patients, especially in the presence of co-morbid behavioural problems.

AIM: To investigate the childhood predictors of HR-QOL in a cohort of adult patients with GTS.

METHODS: Forty-six patients with GTS aged 6-16 years underwent a baseline standardised clinical assessment of both tics and behavioural symptoms at a specialist GTS clinic. The same patients were re-assessed aged 16 years and above, with a mean follow-up period of 13 years (range 3-25 years), when they completed the Gilles de la Tourette Syndrome-Quality of Life Scale (GTS-QOL), a disease-specific measure of HR-QOL.

RESULTS: Tic severity, premonitory urges and family history of GTS were identified as predictors during childhood of a poorer HR-QOL in adults with GTS by multiple linear regression analysis. Specifically, tic severity significantly predicted poor outcome across physical, psychological and cognitive domains of the GTS-QOL, reflecting widespread effects on HR-QOL.

CONCLUSION: Young patients with severe tics associated with characteristic premonitory urges and a family history of tic disorders appear to be at higher risk for poorer HR-QOL as adults. Further prospective research into HR-QOL in GTS is required in order to inform long-term strategic resource allocation.

Original languageEnglish
Pages (from-to)605-12
Number of pages8
JournalEuropean Journal of Paediatric Neurology
Issue number6
Publication statusPublished - Nov 2012


  • Adolescent
  • Adult
  • Aged
  • Child
  • Cross-Sectional Studies
  • Data Interpretation, Statistical
  • Demography
  • Female
  • Humans
  • Interview, Psychological
  • Longitudinal Studies
  • Male
  • Middle Aged
  • Neuropsychological Tests
  • Obsessive-Compulsive Disorder/complications
  • Prognosis
  • Quality of Life/psychology
  • Regression Analysis
  • Resource Allocation
  • Tourette Syndrome/complications
  • Treatment Outcome
  • Young Adult


Dive into the research topics of 'Predictors during childhood of future health-related quality of life in adults with Gilles de la Tourette syndrome'. Together they form a unique fingerprint.

Cite this