Preclinical development of T cell receptor gene therapy

Gavin M Bendle, John B A G Haanen, Ton N M Schumacher

Research output: Contribution to journalArticlepeer-review

46 Citations (Scopus)


The adoptive transfer of TCR gene-modified T cells has been developed with the aim to induce immune reactivity toward defined tumor-associated antigens to which the endogenous T cell repertoire is non-responsive. Here we discuss in which areas preclinical studies in mouse models can or cannot be expected to be of value to guide clinical trial design, and how the available data from preclinical studies should influence forthcoming clinical trials.
Original languageEnglish
Pages (from-to)209-14
Number of pages6
JournalCurrent Opinion in Immunology
Issue number2
Publication statusPublished - Apr 2009


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