Precious metal carborane polymer nanoparticles: characterisation of micellar formulations and anticancer activity

Nicolas P.E. Barry; Anaïs Pitto-Barry; Isolda Romero-Canelón; Johanna Tran; Joan J. Soldevila-Barreda; Ian Hands-Portman; Corinne J. Smith; Nigel Kirby; Andrew P. Dove; Rachel K. O'Reilly; Peter J. Sadler

doi:10.1039/c4fd00098f

Precious metal carborane polymer nanoparticles: characterisation of micellar formulations and anticancer activity

Nicolas P.E. Barry^*, Anaïs Pitto-Barry, Isolda Romero-Canelón, Johanna Tran, Joan J. Soldevila-Barreda, Ian Hands-Portman, Corinne J. Smith, Nigel Kirby, Andrew P. Dove, Rachel K. O'Reilly, Peter J. Sadler

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

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Abstract

We report the encapsulation of highly hydrophobic 16-electron organometallic ruthenium and osmium carborane complexes [Ru/Os(p-cymene)(1,2-dicarba-closo-dodecarborane-1,2-dithiolate)] (1 and 2) in Pluronic® triblock copolymer P123 core-shell micelles. The spherical nanoparticles RuMs and OsMs, dispersed in water, were characterized by dynamic light scattering (DLS), cryogenic transmission electron microscopy (cryo-TEM), and synchrotron small-angle X-ray scattering (SAXS; diameter ca. 15 and 19 nm, respectively). Complexes 1 and 2 were highly active towards A2780 human ovarian cancer cells (IC₅₀ 0.17 and 2.50 μM, respectively) and the encapsulated complexes, as RuMs and OsMs nanoparticles, were less potent (IC₅₀ 6.69 μM and 117.5 μM, respectively), but more selective towards cancer cells compared to normal cells. This journal is

Original language	English
Pages (from-to)	229-240
Number of pages	12
Journal	Faraday Discussions
Volume	175
Early online date	1 Oct 2014
DOIs	https://doi.org/10.1039/c4fd00098f
Publication status	Published - 8 Dec 2014

ASJC Scopus subject areas

Physical and Theoretical Chemistry

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Nicolas_P_E_Barry_et_al_Precious_metal_carborane_polymer_nanoparticles_Faraday_Discussions_2014
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Barry, N. P. E., Pitto-Barry, A., Romero-Canelón, I., Tran, J., Soldevila-Barreda, J. J., Hands-Portman, I., Smith, C. J., Kirby, N., Dove, A. P., O'Reilly, R. K., & Sadler, P. J. (2014). Precious metal carborane polymer nanoparticles: characterisation of micellar formulations and anticancer activity. Faraday Discussions, 175, 229-240. https://doi.org/10.1039/c4fd00098f

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title = "Precious metal carborane polymer nanoparticles: characterisation of micellar formulations and anticancer activity",

abstract = "We report the encapsulation of highly hydrophobic 16-electron organometallic ruthenium and osmium carborane complexes [Ru/Os(p-cymene)(1,2-dicarba-closo-dodecarborane-1,2-dithiolate)] (1 and 2) in Pluronic{\textregistered} triblock copolymer P123 core-shell micelles. The spherical nanoparticles RuMs and OsMs, dispersed in water, were characterized by dynamic light scattering (DLS), cryogenic transmission electron microscopy (cryo-TEM), and synchrotron small-angle X-ray scattering (SAXS; diameter ca. 15 and 19 nm, respectively). Complexes 1 and 2 were highly active towards A2780 human ovarian cancer cells (IC50 0.17 and 2.50 μM, respectively) and the encapsulated complexes, as RuMs and OsMs nanoparticles, were less potent (IC50 6.69 μM and 117.5 μM, respectively), but more selective towards cancer cells compared to normal cells. This journal is",

author = "Barry, {Nicolas P.E.} and Ana{\"i}s Pitto-Barry and Isolda Romero-Canel{\'o}n and Johanna Tran and Soldevila-Barreda, {Joan J.} and Ian Hands-Portman and Smith, {Corinne J.} and Nigel Kirby and Dove, {Andrew P.} and O'Reilly, {Rachel K.} and Sadler, {Peter J.}",

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doi = "10.1039/c4fd00098f",

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AU - Romero-Canelón, Isolda

AU - Tran, Johanna

AU - Soldevila-Barreda, Joan J.

AU - Hands-Portman, Ian

AU - Smith, Corinne J.

AU - Kirby, Nigel

AU - Dove, Andrew P.

AU - O'Reilly, Rachel K.

AU - Sadler, Peter J.

PY - 2014/12/8

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N2 - We report the encapsulation of highly hydrophobic 16-electron organometallic ruthenium and osmium carborane complexes [Ru/Os(p-cymene)(1,2-dicarba-closo-dodecarborane-1,2-dithiolate)] (1 and 2) in Pluronic® triblock copolymer P123 core-shell micelles. The spherical nanoparticles RuMs and OsMs, dispersed in water, were characterized by dynamic light scattering (DLS), cryogenic transmission electron microscopy (cryo-TEM), and synchrotron small-angle X-ray scattering (SAXS; diameter ca. 15 and 19 nm, respectively). Complexes 1 and 2 were highly active towards A2780 human ovarian cancer cells (IC50 0.17 and 2.50 μM, respectively) and the encapsulated complexes, as RuMs and OsMs nanoparticles, were less potent (IC50 6.69 μM and 117.5 μM, respectively), but more selective towards cancer cells compared to normal cells. This journal is

AB - We report the encapsulation of highly hydrophobic 16-electron organometallic ruthenium and osmium carborane complexes [Ru/Os(p-cymene)(1,2-dicarba-closo-dodecarborane-1,2-dithiolate)] (1 and 2) in Pluronic® triblock copolymer P123 core-shell micelles. The spherical nanoparticles RuMs and OsMs, dispersed in water, were characterized by dynamic light scattering (DLS), cryogenic transmission electron microscopy (cryo-TEM), and synchrotron small-angle X-ray scattering (SAXS; diameter ca. 15 and 19 nm, respectively). Complexes 1 and 2 were highly active towards A2780 human ovarian cancer cells (IC50 0.17 and 2.50 μM, respectively) and the encapsulated complexes, as RuMs and OsMs nanoparticles, were less potent (IC50 6.69 μM and 117.5 μM, respectively), but more selective towards cancer cells compared to normal cells. This journal is

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Precious metal carborane polymer nanoparticles: characterisation of micellar formulations and anticancer activity

Abstract

ASJC Scopus subject areas

UN SDGs

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