TY - JOUR
T1 - Pragmatic Lifestyle Intervention in Patients Recovering From Colon Cancer: A Randomized Controlled Pilot Study
AU - Bourke, L
AU - Gibson, DJ
AU - Daley, Amanda
AU - Crank, H
AU - Adam, I
AU - Shorthouse, A
AU - Saxton, J
AU - Thompson, Georgia
PY - 2011/5/1
Y1 - 2011/5/1
N2 - Objective: To investigate the feasibility of a pragmatic lifestyle intervention in patients who had recently completed surgery and chemotherapy for colon cancer and to obtain preliminary data of its impact on important health outcomes.
Design: A prospective, randomized, controlled pilot trial.
Setting: University rehabilitation facility.
Participants: Eighteen (N=18) colon cancer survivors (mean age=69y; range, 52-80y), Dukes stage A to C.
Interventions: Participants were randomized 6 to 24 months postoperatively to either a 12-week program of combined exercise and dietary advice or standard treatment.
Main Outcome Measures: Exercise and dietary behavior, fatigue, health-related quality of life (QOL), aerobic exercise tolerance, functional capacity, muscle strength, and anthropometery were assessed at baseline and immediately after the intervention.
Results: Adherences to supervised and independent exercise during the intervention were 90% and 94%, respectively, and there was low attrition (6%). The lifestyle intervention elicited improvements in exercise behavior (P=.068), fatigue (P=.005), aerobic exercise tolerance (P=.010), chair sit-to-stand performance (P=.003), and waist-to-hip ratio (P=.002). A positive change in dietary fiber intake (P=.044) was also observed in the intervention group. No change in QOL was observed (P=.795).
Conclusions: These preliminary results suggest that a pragmatic lifestyle intervention implemented 6 to 24 months after primary treatment for colon cancer was feasible. We observed a significant impact on dietary behavior, fatigue, aerobic exercise tolerance, functional capacity, and waist-to-hip ratio. These findings need to be confirmed with a larger-scale definitive randomized controlled trial.
AB - Objective: To investigate the feasibility of a pragmatic lifestyle intervention in patients who had recently completed surgery and chemotherapy for colon cancer and to obtain preliminary data of its impact on important health outcomes.
Design: A prospective, randomized, controlled pilot trial.
Setting: University rehabilitation facility.
Participants: Eighteen (N=18) colon cancer survivors (mean age=69y; range, 52-80y), Dukes stage A to C.
Interventions: Participants were randomized 6 to 24 months postoperatively to either a 12-week program of combined exercise and dietary advice or standard treatment.
Main Outcome Measures: Exercise and dietary behavior, fatigue, health-related quality of life (QOL), aerobic exercise tolerance, functional capacity, muscle strength, and anthropometery were assessed at baseline and immediately after the intervention.
Results: Adherences to supervised and independent exercise during the intervention were 90% and 94%, respectively, and there was low attrition (6%). The lifestyle intervention elicited improvements in exercise behavior (P=.068), fatigue (P=.005), aerobic exercise tolerance (P=.010), chair sit-to-stand performance (P=.003), and waist-to-hip ratio (P=.002). A positive change in dietary fiber intake (P=.044) was also observed in the intervention group. No change in QOL was observed (P=.795).
Conclusions: These preliminary results suggest that a pragmatic lifestyle intervention implemented 6 to 24 months after primary treatment for colon cancer was feasible. We observed a significant impact on dietary behavior, fatigue, aerobic exercise tolerance, functional capacity, and waist-to-hip ratio. These findings need to be confirmed with a larger-scale definitive randomized controlled trial.
KW - Fatigue
KW - Rehabilitation
KW - Exercise
KW - Diet
KW - Colonic neoplasms
U2 - 10.1016/j.apmr.2010.12.020
DO - 10.1016/j.apmr.2010.12.020
M3 - Article
C2 - 21530722
SN - 1532-821X
VL - 92
SP - 749
EP - 755
JO - Archives of Physical Medicine and Rehabilitation
JF - Archives of Physical Medicine and Rehabilitation
IS - 5
ER -