Power-law scaling in intratumoral microbiota of colorectal cancer

Nikolas Dovrolis; Maria Gazouli; François Rigal; Robert J. Whittaker; Thomas J. Matthews; Konstantinos Georgiou; George Theodoropoulos; Kostas A. Triantis

doi:10.1186/s13099-024-00631-x

Power-law scaling in intratumoral microbiota of colorectal cancer

Nikolas Dovrolis^*
, Maria Gazouli^*
, François Rigal
, Robert J. Whittaker
, Thomas J. Matthews
, Konstantinos Georgiou
, George Theodoropoulos
, Kostas A. Triantis^*

^*Corresponding author for this work

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Abstract

It has recently been proposed that the study of microbial dynamics in humans may gain insights from island biogeographical theory. Here, we test whether the diversity of the intratumoral microbiota of colorectal cancer tumors (CRC) follows a power law with tumor size akin to the island species-area relationship. We confirm a direct correlation between the quantity of Amplicon Sequence Variants (ASVs) within CRC tumors and tumor sizes, following a (log)power model, explaining 47% of the variation. Understanding the processes involved, potentially through the analogy of tumors and islands, may ultimately contribute to future clinical and therapeutic strategies.

Original language	English
Article number	34
Number of pages	4
Journal	Gut Pathogens
Volume	16
Issue number	1
DOIs	https://doi.org/10.1186/s13099-024-00631-x
Publication status	Published - 7 Jul 2024

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Intratumoral microbiome
Cancer
Island species–area relationship

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DovrolisN2024PowerFinal published version, 972 KBLicence: Creative Commons: Attribution (CC BY)

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title = "Power-law scaling in intratumoral microbiota of colorectal cancer",

abstract = "It has recently been proposed that the study of microbial dynamics in humans may gain insights from island biogeographical theory. Here, we test whether the diversity of the intratumoral microbiota of colorectal cancer tumors (CRC) follows a power law with tumor size akin to the island species-area relationship. We confirm a direct correlation between the quantity of Amplicon Sequence Variants (ASVs) within CRC tumors and tumor sizes, following a (log)power model, explaining 47\% of the variation. Understanding the processes involved, potentially through the analogy of tumors and islands, may ultimately contribute to future clinical and therapeutic strategies.",

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AU - Dovrolis, Nikolas

AU - Gazouli, Maria

AU - Rigal, François

AU - Whittaker, Robert J.

AU - Matthews, Thomas J.

AU - Georgiou, Konstantinos

AU - Theodoropoulos, George

AU - Triantis, Kostas A.

PY - 2024/7/7

Y1 - 2024/7/7

N2 - It has recently been proposed that the study of microbial dynamics in humans may gain insights from island biogeographical theory. Here, we test whether the diversity of the intratumoral microbiota of colorectal cancer tumors (CRC) follows a power law with tumor size akin to the island species-area relationship. We confirm a direct correlation between the quantity of Amplicon Sequence Variants (ASVs) within CRC tumors and tumor sizes, following a (log)power model, explaining 47% of the variation. Understanding the processes involved, potentially through the analogy of tumors and islands, may ultimately contribute to future clinical and therapeutic strategies.

AB - It has recently been proposed that the study of microbial dynamics in humans may gain insights from island biogeographical theory. Here, we test whether the diversity of the intratumoral microbiota of colorectal cancer tumors (CRC) follows a power law with tumor size akin to the island species-area relationship. We confirm a direct correlation between the quantity of Amplicon Sequence Variants (ASVs) within CRC tumors and tumor sizes, following a (log)power model, explaining 47% of the variation. Understanding the processes involved, potentially through the analogy of tumors and islands, may ultimately contribute to future clinical and therapeutic strategies.

KW - Intratumoral microbiome

KW - Cancer

KW - Island species–area relationship

U2 - 10.1186/s13099-024-00631-x

DO - 10.1186/s13099-024-00631-x

M3 - Article

SN - 1757-4749

VL - 16

JO - Gut Pathogens

JF - Gut Pathogens

IS - 1

M1 - 34

ER -

Power-law scaling in intratumoral microbiota of colorectal cancer

Abstract

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Keywords

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