Potential Antitumor Effect of α-Mangostin against Rat Mammary Gland Tumors Induced by LA7 Cells

Mohamed Yousif Ibrahim; Najihah Mohd Hashim; Fatima Abdelmutaal Ahmed Omer; Muhammad Salisu Abubakar; Hoyam Adam Mohammed; Suzy Munir Salama; Soher Nagi Jayash; Adam Jarmuła; Piotr Maj

doi:10.3390/ijms241210283

Potential Antitumor Effect of α-Mangostin against Rat Mammary Gland Tumors Induced by LA7 Cells

Mohamed Yousif Ibrahim^*
, Najihah Mohd Hashim
, Fatima Abdelmutaal Ahmed Omer
, Muhammad Salisu Abubakar
, Hoyam Adam Mohammed
, Suzy Munir Salama
, Soher Nagi Jayash^*
, Adam Jarmuła (Editor)
, Piotr Maj (Editor)

^*Corresponding author for this work

Dentistry

Research output: Contribution to journal › Article › peer-review

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Abstract

In this study, the chemotherapeutic effect of α-mangostin (AM) was assessed in rats injected with LA7 cells. Rats received AM orally at 30 and 60 mg/kg twice a week for 4 weeks. Cancer biomarkers such as CEA and CA 15-3 were significantly lower in AM-treated rats. Histopathological evaluations showed that AM protects the rat mammary gland from the carcinogenic effects of LA7 cells. Interestingly, AM decreased lipid peroxidation and increased antioxidant enzymes when compared to the control. Immunohistochemistry results of the untreated rats showed abundant PCNA and fewer p53-positive cells than AM-treated rats. Using the TUNEL test, AM-treated animals had higher apoptotic cell numbers than those untreated. This report revealed that that AM lessened oxidative stress, suppressed proliferation, and minimized LA7-induced mammary carcinogenesis. Therefore, the current study suggests that AM has significant potential for breast cancer treatment.

Original language	English
Article number	10283
Journal	International Journal of Molecular Sciences
Volume	24
Issue number	12
DOIs	https://doi.org/10.3390/ijms241210283
Publication status	Published - 17 Jun 2023

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

mammary cancer
LA7 cells
immunohistochemistry
α-mangostin
antioxidant
apoptosis

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title = "Potential Antitumor Effect of α-Mangostin against Rat Mammary Gland Tumors Induced by LA7 Cells",

abstract = "In this study, the chemotherapeutic effect of α-mangostin (AM) was assessed in rats injected with LA7 cells. Rats received AM orally at 30 and 60 mg/kg twice a week for 4 weeks. Cancer biomarkers such as CEA and CA 15-3 were significantly lower in AM-treated rats. Histopathological evaluations showed that AM protects the rat mammary gland from the carcinogenic effects of LA7 cells. Interestingly, AM decreased lipid peroxidation and increased antioxidant enzymes when compared to the control. Immunohistochemistry results of the untreated rats showed abundant PCNA and fewer p53-positive cells than AM-treated rats. Using the TUNEL test, AM-treated animals had higher apoptotic cell numbers than those untreated. This report revealed that that AM lessened oxidative stress, suppressed proliferation, and minimized LA7-induced mammary carcinogenesis. Therefore, the current study suggests that AM has significant potential for breast cancer treatment.",

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author = "Ibrahim, \{Mohamed Yousif\} and Hashim, \{Najihah Mohd\} and Omer, \{Fatima Abdelmutaal Ahmed\} and Abubakar, \{Muhammad Salisu\} and Mohammed, \{Hoyam Adam\} and Salama, \{Suzy Munir\} and Jayash, \{Soher Nagi\} and Adam Jarmu{\l}a and Piotr Maj",

year = "2023",

month = jun,

day = "17",

doi = "10.3390/ijms241210283",

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T1 - Potential Antitumor Effect of α-Mangostin against Rat Mammary Gland Tumors Induced by LA7 Cells

AU - Ibrahim, Mohamed Yousif

AU - Hashim, Najihah Mohd

AU - Omer, Fatima Abdelmutaal Ahmed

AU - Abubakar, Muhammad Salisu

AU - Mohammed, Hoyam Adam

AU - Salama, Suzy Munir

AU - Jayash, Soher Nagi

A2 - Jarmuła, Adam

A2 - Maj, Piotr

PY - 2023/6/17

Y1 - 2023/6/17

N2 - In this study, the chemotherapeutic effect of α-mangostin (AM) was assessed in rats injected with LA7 cells. Rats received AM orally at 30 and 60 mg/kg twice a week for 4 weeks. Cancer biomarkers such as CEA and CA 15-3 were significantly lower in AM-treated rats. Histopathological evaluations showed that AM protects the rat mammary gland from the carcinogenic effects of LA7 cells. Interestingly, AM decreased lipid peroxidation and increased antioxidant enzymes when compared to the control. Immunohistochemistry results of the untreated rats showed abundant PCNA and fewer p53-positive cells than AM-treated rats. Using the TUNEL test, AM-treated animals had higher apoptotic cell numbers than those untreated. This report revealed that that AM lessened oxidative stress, suppressed proliferation, and minimized LA7-induced mammary carcinogenesis. Therefore, the current study suggests that AM has significant potential for breast cancer treatment.

AB - In this study, the chemotherapeutic effect of α-mangostin (AM) was assessed in rats injected with LA7 cells. Rats received AM orally at 30 and 60 mg/kg twice a week for 4 weeks. Cancer biomarkers such as CEA and CA 15-3 were significantly lower in AM-treated rats. Histopathological evaluations showed that AM protects the rat mammary gland from the carcinogenic effects of LA7 cells. Interestingly, AM decreased lipid peroxidation and increased antioxidant enzymes when compared to the control. Immunohistochemistry results of the untreated rats showed abundant PCNA and fewer p53-positive cells than AM-treated rats. Using the TUNEL test, AM-treated animals had higher apoptotic cell numbers than those untreated. This report revealed that that AM lessened oxidative stress, suppressed proliferation, and minimized LA7-induced mammary carcinogenesis. Therefore, the current study suggests that AM has significant potential for breast cancer treatment.

KW - mammary cancer

KW - LA7 cells

KW - immunohistochemistry

KW - α-mangostin

KW - antioxidant

KW - apoptosis

U2 - 10.3390/ijms241210283

DO - 10.3390/ijms241210283

M3 - Article

C2 - 37373429

SN - 1661-6596

VL - 24

JO - International Journal of Molecular Sciences

JF - International Journal of Molecular Sciences

IS - 12

M1 - 10283

ER -

Potential Antitumor Effect of α-Mangostin against Rat Mammary Gland Tumors Induced by LA7 Cells

Abstract

UN SDGs

Keywords

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