Post-transcriptional gene regulation by MAP kinases via AU-rich elements

Andrew Clark, Jonathan Dean, Corina Tudor, Jeremy Saklatvala

Research output: Contribution to journalArticlepeer-review

49 Citations (Scopus)

Abstract

Eukaryotic cells must continuously sense their environments, for example their attachment to extracellular matrix and proximity to other cells, differences in temperature or redox conditions, the presence of nutrients, growth factors, hormones, cytokines or pathogens. The information must then be integrated and an appropriate response initiated by modulating the cellular programme of gene expression. The mitogen-activated protein kinase (MAPK) signaling pathways play a critical role in this process. Decades of research have illuminated the many ways in which MAPKs regulate the synthesis of mRNA (transcription) via phosphorylation of transcription factors, cofactors, and other proteins. In recent years it has become increasingly clear that the control of mRNA destruction is equally important for cellular responses to extracellular cues, and is equally subject to regulation by MAPKs. This review will summarize our current understanding of post-transcriptional regulation of gene expression by the MAPKs and the proteins that are involved in this process.

Original languageEnglish
Pages (from-to)847-871
Number of pages25
JournalFrontiers in Bioscience
Volume14
Issue number3
DOIs
Publication statusPublished - 1 Jan 2009

Keywords

  • Adenylate/uridylate-rich element
  • Auf
  • Cytokine production
  • ERK
  • HuR
  • Inflammation
  • JNK
  • KSRP
  • Mitogen-activated protein kinase
  • MRNA stability
  • MRNA translation
  • P38 MAPK
  • Posttranscriptional regulation
  • Processing body
  • Protein phosphorylation
  • Review
  • Tristetraprolin

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Immunology and Microbiology(all)

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