TY - JOUR
T1 - Post-hospitalisation COVID-19 cognitive deficits at one year are global and associated with elevated brain injury markers and grey matter volume reduction
AU - COVID-CNS Consortium
AU - Wood, Greta K
AU - Sargent, Brendan F
AU - Ahmad, Zain-Ul-Abideen
AU - Tharmaratnam, Kukatharmini
AU - Dunai, Cordelia
AU - Egbe, Franklyn N
AU - Martin, Naomi H
AU - Facer, Bethany
AU - Pendered, Sophie L
AU - Rogers, Henry C
AU - Hübel, Christopher
AU - van Wamelen, Daniel J
AU - Bethlehem, Richard A I
AU - Giunchiglia, Valentina
AU - Hellyer, Peter J
AU - Trender, William
AU - Kalsi, Gursharan
AU - Needham, Edward
AU - Easton, Ava
AU - Jackson, Thomas A
AU - Cunningham, Colm
AU - Upthegrove, Rachel
AU - Pollak, Thomas A
AU - Hotopf, Matthew
AU - Solomon, Tom
AU - Pett, Sarah L
AU - Shaw, Pamela J
AU - Wood, Nicholas
AU - Harrison, Neil A
AU - Miller, Karla L
AU - Jezzard, Peter
AU - Williams, Guy
AU - Duff, Eugene P
AU - Williams, Steven
AU - Zelaya, Fernando
AU - Smith, Stephen M
AU - Keller, Simon
AU - Broome, Matthew
AU - Kingston, Nathalie
AU - Husain, Masud
AU - Vincent, Angela
AU - Bradley, John
AU - Chinnery, Patrick
AU - Menon, David K
AU - Aggleton, John P
AU - Nicholson, Timothy R
AU - Taylor, John-Paul
AU - David, Anthony S
AU - Carson, Alan
AU - Bullmore, Ed
AU - Veenith, Tonny
N1 - © 2024. The Author(s), under exclusive licence to Springer Nature America, Inc.
PY - 2024/9/23
Y1 - 2024/9/23
N2 - The spectrum, pathophysiology, and recovery trajectory of persistent post-COVID-19 cognitive deficits are unknown, limiting our ability to develop prevention and treatment strategies. We report the one-year cognitive, serum biomarker, and neuroimaging findings from a prospective, national study of cognition in 351 COVID-19 patients who had required hospitalisation, compared to 2,927 normative matched controls. Cognitive deficits were global and associated with elevated brain injury markers, and reduced anterior cingulate cortex volume one year after COVID-19. The severity of the initial infective insult, post-acute psychiatric symptoms, and a history of encephalopathy were associated with greatest deficits. There was strong concordance between subjective and objective cognitive deficits. Longitudinal follow-up in 106 patients demonstrated a trend toward recovery. Together, these findings support the hypothesis that brain injury in moderate to severe COVID-19 may be immune-mediated, and should guide the development of therapeutic strategies.
AB - The spectrum, pathophysiology, and recovery trajectory of persistent post-COVID-19 cognitive deficits are unknown, limiting our ability to develop prevention and treatment strategies. We report the one-year cognitive, serum biomarker, and neuroimaging findings from a prospective, national study of cognition in 351 COVID-19 patients who had required hospitalisation, compared to 2,927 normative matched controls. Cognitive deficits were global and associated with elevated brain injury markers, and reduced anterior cingulate cortex volume one year after COVID-19. The severity of the initial infective insult, post-acute psychiatric symptoms, and a history of encephalopathy were associated with greatest deficits. There was strong concordance between subjective and objective cognitive deficits. Longitudinal follow-up in 106 patients demonstrated a trend toward recovery. Together, these findings support the hypothesis that brain injury in moderate to severe COVID-19 may be immune-mediated, and should guide the development of therapeutic strategies.
U2 - 10.1038/s41591-024-03309-8
DO - 10.1038/s41591-024-03309-8
M3 - Article
C2 - 39312956
SN - 1078-8956
JO - Nature Medicine
JF - Nature Medicine
ER -