Possession of the HLA-DRB1*1501 allele and visual outcome in idiopathic intermediate uveitis

Harry Petrushkin, Dhanes Thomas, Robert Vaughan, Elli Kondeatis, Miles R Stanford, Clive Edelsten, Graham R Wallace

Research output: Contribution to journalLetterpeer-review

1 Citation (Scopus)


Idiopathic intermediate uveitis (IIU) is a potentially sight-threatening inflammatory disease characterized by breakdown of the blood-retina barrier with consequent leukocytic infiltration of the vitreous and retina. Poor visual outcome has been associated with cystoid macular edema, poor vision at presentation, and male sex.1 The human leukocyte antigen (HLA) allele DRB1*1501 has long been associated with multiple sclerosis (MS). Tang et al2 prospectively analyzed 18 patients and found that HLA-DRB1*1501 conferred increased risk of developing IIU associated with MS in some patients.

The purposes of this study were to prospectively evaluate the association between the HLA-DRB1*1501 allele and IIU in patients and to determine whether HLA-DRB1*1501 might be a separate independent risk factor for visual loss.
Original languageEnglish
Pages (from-to)482-483
Number of pages2
JournalJAMA Ophthalmology
Issue number4
Early online date29 Jan 2015
Publication statusPublished - Apr 2015


  • Alleles
  • Female
  • Follow-Up Studies
  • HLA-DRB1 Chains
  • Humans
  • Male
  • Middle Aged
  • Prospective Studies
  • Uveitis, Intermediate
  • Visual Acuity


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