Polyunsaturated fatty acids and inflammation

Rachel Marion-Letellier, Guillaume Savoye, Subrata Ghosh

Research output: Contribution to journalReview articlepeer-review

79 Citations (Scopus)

Abstract

Inflammation is a protective process for life that aims to restore body homeostasis by targeting the injury and by inducing repair mechanisms. This process can also become excessive and lead to chronic inflammation and organ fibrosis. Polyunsaturated fatty acids play a key role in inflammatory processes and their resolution. Indeed, numerous lipid mediators derived from n-3 or n-6 PUFA such as eicosanoids, endocannabinoids, or proresolving lipids are able to target transcription factors to modulate gene expression. One other important action mechanism is by modification of cell membrane composition. The purpose of the present review is to describe the potential mechanisms by which PUFA influence inflammatory processes. To illustrate this purpose, we focused on the interactions between PUFA and intestinal inflammation as an integrative example.

Original languageEnglish
Pages (from-to)659-667
Number of pages9
JournalIUBMB Life
Volume67
Issue number9
DOIs
Publication statusPublished - 23 Sep 2015

Keywords

  • Animals
  • Fatty Acids, Unsaturated
  • Humans
  • Inflammation
  • Journal Article
  • Review

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