Polypyrimidine tract binding protein functions as a negative regulator of feline calicivirus translation

Ioannis Karakasiliotis; Surender Vashist; Dalan Bailey; Eugenio J Abente; Kim Y Green; Lisa O Roberts; Stanislav V Sosnovtsev; Ian G Goodfellow

doi:10.1371/journal.pone.0009562

Polypyrimidine tract binding protein functions as a negative regulator of feline calicivirus translation

Ioannis Karakasiliotis
, Surender Vashist
, Dalan Bailey
, Eugenio J Abente
, Kim Y Green
, Lisa O Roberts
, Stanislav V Sosnovtsev
, Ian G Goodfellow

Immunology and Immunotherapy

Research output: Contribution to journal › Article › peer-review

27 Citations (Scopus)

Abstract

Positive strand RNA viruses rely heavily on host cell RNA binding proteins for various aspects of their life cycle. Such proteins interact with sequences usually present at the 5' or 3' extremities of the viral RNA genome, to regulate viral translation and/or replication. We have previously reported that the well characterized host RNA binding protein polypyrimidine tract binding protein (PTB) interacts with the 5'end of the feline calicivirus (FCV) genomic and subgenomic RNAs, playing a role in the FCV life cycle.

Original language	English
Pages (from-to)	e9562
Journal	PLoS ONE
Volume	5
Issue number	3
DOIs	https://doi.org/10.1371/journal.pone.0009562
Publication status	Published - 2010

Keywords

Animals
Binding Sites
Calicivirus, Feline
Cats
Cell Line
Cell Nucleus
Cytoplasm
Gene Expression Regulation, Viral
Genome, Viral
Green Fluorescent Proteins
Mutation
Polypyrimidine Tract-Binding Protein
Protein Binding
Protein Biosynthesis
RNA, Small Interfering
Ribonuclease H
Virus Replication

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Cite this

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title = "Polypyrimidine tract binding protein functions as a negative regulator of feline calicivirus translation",

abstract = "Positive strand RNA viruses rely heavily on host cell RNA binding proteins for various aspects of their life cycle. Such proteins interact with sequences usually present at the 5' or 3' extremities of the viral RNA genome, to regulate viral translation and/or replication. We have previously reported that the well characterized host RNA binding protein polypyrimidine tract binding protein (PTB) interacts with the 5'end of the feline calicivirus (FCV) genomic and subgenomic RNAs, playing a role in the FCV life cycle.",

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author = "Ioannis Karakasiliotis and Surender Vashist and Dalan Bailey and Abente, \{Eugenio J\} and Green, \{Kim Y\} and Roberts, \{Lisa O\} and Sosnovtsev, \{Stanislav V\} and Goodfellow, \{Ian G\}",

year = "2010",

doi = "10.1371/journal.pone.0009562",

language = "English",

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T1 - Polypyrimidine tract binding protein functions as a negative regulator of feline calicivirus translation

AU - Karakasiliotis, Ioannis

AU - Vashist, Surender

AU - Bailey, Dalan

AU - Abente, Eugenio J

AU - Green, Kim Y

AU - Roberts, Lisa O

AU - Sosnovtsev, Stanislav V

AU - Goodfellow, Ian G

PY - 2010

Y1 - 2010

N2 - Positive strand RNA viruses rely heavily on host cell RNA binding proteins for various aspects of their life cycle. Such proteins interact with sequences usually present at the 5' or 3' extremities of the viral RNA genome, to regulate viral translation and/or replication. We have previously reported that the well characterized host RNA binding protein polypyrimidine tract binding protein (PTB) interacts with the 5'end of the feline calicivirus (FCV) genomic and subgenomic RNAs, playing a role in the FCV life cycle.

AB - Positive strand RNA viruses rely heavily on host cell RNA binding proteins for various aspects of their life cycle. Such proteins interact with sequences usually present at the 5' or 3' extremities of the viral RNA genome, to regulate viral translation and/or replication. We have previously reported that the well characterized host RNA binding protein polypyrimidine tract binding protein (PTB) interacts with the 5'end of the feline calicivirus (FCV) genomic and subgenomic RNAs, playing a role in the FCV life cycle.

KW - Animals

KW - Binding Sites

KW - Calicivirus, Feline

KW - Cats

KW - Cell Line

KW - Cell Nucleus

KW - Cytoplasm

KW - Gene Expression Regulation, Viral

KW - Genome, Viral

KW - Green Fluorescent Proteins

KW - Mutation

KW - Polypyrimidine Tract-Binding Protein

KW - Protein Binding

KW - Protein Biosynthesis

KW - RNA, Small Interfering

KW - Ribonuclease H

KW - Virus Replication

U2 - 10.1371/journal.pone.0009562

DO - 10.1371/journal.pone.0009562

M3 - Article

C2 - 20224775

SN - 1932-6203

VL - 5

SP - e9562

JO - PLoS ONE

JF - PLoS ONE

IS - 3

ER -

Polypyrimidine tract binding protein functions as a negative regulator of feline calicivirus translation

Abstract

Keywords

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