Polymorphism of a novel sodium ion channel blocker

Eugene Cheung, Kenneth Harris, Roy Johnston, KL Hadden, M Zakrzewski

Research output: Contribution to journalArticle

5 Citations (Scopus)


2-[[4-(4-Fluorophenoxy)phenyl]-methylene]-hydrazinecarboxamide, a member of the semicarbazone family which has shown potential therapeutic use as anticonvulsants, has been found to exist in two polymorphic forms denoted A and B. In addition to reporting aspects of the physical characterization of both forms, the crystal structure of polymorph A has been determined directly from powder X-ray diffraction data using the Genetic Algorithm technique for structure solution, followed by Rietveld refinement. This structure is compared with that of polymorph B, which was determined previously from single crystal X-ray diffraction data. Knowledge of the crystal structures of the two polymorphs provides the opportunity for establishing structure-property relationships. This work further emphasizes the scope and utility of ab initio structure solution from powder X-ray diffraction data in the pharmaceuticals field.
Original languageEnglish
Pages (from-to)2017-2026
Number of pages10
JournalJournal of Pharmaceutical Sciences
Issue number10
Early online date16 Sept 2003
Publication statusPublished - 1 Oct 2003


  • crystal structure determination
  • polymorphism
  • genetic algorithm
  • powder X-ray diffraction
  • Rietveld refinement


Dive into the research topics of 'Polymorphism of a novel sodium ion channel blocker'. Together they form a unique fingerprint.

Cite this