Polyion complex (PIC) particles: Preparation and biomedical applications

Ignacio Insua, Andrew Wilkinson, Francisco Fernandez-Trillo*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

50 Citations (Scopus)
218 Downloads (Pure)


Oppositely charged polyions can self-assemble in solution to form colloidal polyion complex (PIC) particles. Such nanomaterials can be loaded with charged therapeutics such as DNA, drugs or probes for application as novel nanomedicines and chemical sensors to detect disease markers. A comprehensive discussion of the factors affecting PIC particle self-assembly and their response to physical and chemical stimuli in solution is described herein. Finally, a collection of key examples of polyionic nanoparticles for biomedical applications is discussed to illustrate their behaviour and demonstrate the potential of PIC nanoparticles in medicine.

Original languageEnglish
Pages (from-to)198-215
Number of pages18
JournalEuropean Polymer Journal
Early online date6 Jun 2016
Publication statusPublished - 1 Aug 2016

ASJC Scopus subject areas

  • Polymers and Plastics
  • Physics and Astronomy(all)
  • Organic Chemistry


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