Polyion complex (PIC) particles: Preparation and biomedical applications

Ignacio Insua; Andrew Wilkinson; Francisco Fernandez-Trillo

doi:10.1016/j.eurpolymj.2016.06.003

Polyion complex (PIC) particles: Preparation and biomedical applications

Ignacio Insua, Andrew Wilkinson, Francisco Fernandez-Trillo^*

^*Corresponding author for this work

Chemistry

Research output: Contribution to journal › Article › peer-review

50 Citations (Scopus)

261 Downloads (Pure)

Abstract

Oppositely charged polyions can self-assemble in solution to form colloidal polyion complex (PIC) particles. Such nanomaterials can be loaded with charged therapeutics such as DNA, drugs or probes for application as novel nanomedicines and chemical sensors to detect disease markers. A comprehensive discussion of the factors affecting PIC particle self-assembly and their response to physical and chemical stimuli in solution is described herein. Finally, a collection of key examples of polyionic nanoparticles for biomedical applications is discussed to illustrate their behaviour and demonstrate the potential of PIC nanoparticles in medicine.

Original language	English
Pages (from-to)	198-215
Number of pages	18
Journal	European Polymer Journal
Volume	81
Early online date	6 Jun 2016
DOIs	https://doi.org/10.1016/j.eurpolymj.2016.06.003
Publication status	Published - 1 Aug 2016

ASJC Scopus subject areas

Polymers and Plastics
Physics and Astronomy(all)
Organic Chemistry

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author = "Ignacio Insua and Andrew Wilkinson and Francisco Fernandez-Trillo",

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AU - Insua, Ignacio

AU - Wilkinson, Andrew

AU - Fernandez-Trillo, Francisco

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AB - Oppositely charged polyions can self-assemble in solution to form colloidal polyion complex (PIC) particles. Such nanomaterials can be loaded with charged therapeutics such as DNA, drugs or probes for application as novel nanomedicines and chemical sensors to detect disease markers. A comprehensive discussion of the factors affecting PIC particle self-assembly and their response to physical and chemical stimuli in solution is described herein. Finally, a collection of key examples of polyionic nanoparticles for biomedical applications is discussed to illustrate their behaviour and demonstrate the potential of PIC nanoparticles in medicine.

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JO - European Polymer Journal

JF - European Polymer Journal

ER -

Polyion complex (PIC) particles: Preparation and biomedical applications

Abstract

ASJC Scopus subject areas

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