Pneumolysin stimulates production of tumor necrosis factor alpha and interleukin-1 beta by human mononuclear phagocytes

S Houldsworth; P W Andrew; T J Mitchell

Pneumolysin stimulates production of tumor necrosis factor alpha and interleukin-1 beta by human mononuclear phagocytes

S Houldsworth
, P W Andrew
, T J Mitchell

Microbes, Infection and Microbiomes

Research output: Contribution to journal › Article › peer-review

154 Citations (Scopus)

Abstract

Human peripheral blood monocytes and a human monocyte cell line were exposed to the toxin pneumolysin. Pneumolysin-exposed cells produced significantly larger amounts of tumor necrosis factor alpha and interleukin-1 beta than cells not exposed to the toxin. The viability of cells was not affected by the concentrations of pneumolysin used in the experiments.

Original language	English
Pages (from-to)	1501-3
Number of pages	3
Journal	Infection and Immunity
Volume	62
Issue number	4
Publication status	Published - Apr 1994

Keywords

Bacterial Proteins
Cell Line
Cytotoxins
Humans
Interleukin-1
Lipopolysaccharides
Monocytes
Streptolysins
Tumor Necrosis Factor-alpha

Cite this

@article{985cb3aa3c5d4976bd68dbd34fb5b2b9,

title = "Pneumolysin stimulates production of tumor necrosis factor alpha and interleukin-1 beta by human mononuclear phagocytes",

abstract = "Human peripheral blood monocytes and a human monocyte cell line were exposed to the toxin pneumolysin. Pneumolysin-exposed cells produced significantly larger amounts of tumor necrosis factor alpha and interleukin-1 beta than cells not exposed to the toxin. The viability of cells was not affected by the concentrations of pneumolysin used in the experiments.",

keywords = "Bacterial Proteins, Cell Line, Cytotoxins, Humans, Interleukin-1, Lipopolysaccharides, Monocytes, Streptolysins, Tumor Necrosis Factor-alpha",

author = "S Houldsworth and Andrew, \{P W\} and Mitchell, \{T J\}",

year = "1994",

month = apr,

language = "English",

volume = "62",

pages = "1501--3",

journal = "Infection and Immunity",

issn = "0019-9567",

publisher = "American Society for Microbiology",

number = "4",

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TY - JOUR

T1 - Pneumolysin stimulates production of tumor necrosis factor alpha and interleukin-1 beta by human mononuclear phagocytes

AU - Houldsworth, S

AU - Andrew, P W

AU - Mitchell, T J

PY - 1994/4

Y1 - 1994/4

N2 - Human peripheral blood monocytes and a human monocyte cell line were exposed to the toxin pneumolysin. Pneumolysin-exposed cells produced significantly larger amounts of tumor necrosis factor alpha and interleukin-1 beta than cells not exposed to the toxin. The viability of cells was not affected by the concentrations of pneumolysin used in the experiments.

AB - Human peripheral blood monocytes and a human monocyte cell line were exposed to the toxin pneumolysin. Pneumolysin-exposed cells produced significantly larger amounts of tumor necrosis factor alpha and interleukin-1 beta than cells not exposed to the toxin. The viability of cells was not affected by the concentrations of pneumolysin used in the experiments.

KW - Bacterial Proteins

KW - Cell Line

KW - Cytotoxins

KW - Humans

KW - Interleukin-1

KW - Lipopolysaccharides

KW - Monocytes

KW - Streptolysins

KW - Tumor Necrosis Factor-alpha

M3 - Article

C2 - 8132361

SN - 0019-9567

VL - 62

SP - 1501

EP - 1503

JO - Infection and Immunity

JF - Infection and Immunity

IS - 4

ER -

Pneumolysin stimulates production of tumor necrosis factor alpha and interleukin-1 beta by human mononuclear phagocytes

Abstract

Keywords

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